Research Investigators

2008-2011
James Bann
Structural characterization of the Anthrax toxin protective antigen

Scott Hefty
Mechanism and role of a novel Chlamydial transcriptional regulator CHXR

Roberto De Guzman, Ph.D.
Interactions of Salmonella needle and tip proteins
NMR studies of protein-protein interactions in the bacterial type III secretion

Heather Desaire, Ph.D.
Structural Characterization of Glycoproteins using Mass Spectrometry

Susan Egan, Ph.D.
Protein-Protein Interactions Required for Transcription Activation by RhaR

2002-2004
William Picking, Ph.D.
Subversion of Eukaryotic Cell Function by Shigella

Center for Biomedical Research Excellence in Protein Structure and Function
Department of Medicinal Chemistry, School of Pharmacy
The University of Kansas

This project is supported by grants from the National Center for Research Resources (5 P20 RR017708) and the National Institute of General Medical Sciences (8 P20 GM 103420).


COBRE Investigators and Their Research Faculty that are selected to become COBRE investigators are early in their careers and are establishing research programs with significant emphasis on protein structure and function. COBRE investigators receive research support and mentoring by a senior faculty advisor. In addition to a developing a specific research plan, COBRE investigators set specific goals for developing and submitting proposals for independent external research support. 2010-Present
	Moriah Beck Palladin and regulation of actin dynamics	John Karanicolas Modulating protein function by rational design

	Alexander Moise Structural characterization of cysteine-dependent acyltransferases	Jeroen Roelofs Mechanism of chaperone-assisted assembly of proteasome regulatory particle
Past COBRE Investigators 2008-2011 James Bann Structural characterization of the Anthrax toxin protective antigen Christopher Fischer Remodeler translocation along DNA Todd Holyoak The role of dynamics in PEPCK mediated catalysis 2008-2010 Scott Hefty Mechanism and role of a novel Chlamydial transcriptional regulator CHXR 2005-2008 Roberto De Guzman, Ph.D. Interactions of Salmonella needle and tip proteins NMR studies of protein-protein interactions in the bacterial type III secretion Audrey Lamb, Ph.D. The Structural Biology of Pyoverdin Biosynthesis Jennifer Laurence, Ph.D. Redox Effects on the Structure and Dynamics of PRL-1 Julian Limburg, Ph.D. Structure and Function of Bacterial Prolyl-4-Hydroxylase Emily Scott, Ph.D. Structure-Function of Mammalian Cytochromes P450 Liskin Swint-Kruse, Ph.D. Allosteric Determinants in the Laci/Galr Family 2002-2005 Brian Blagg, Ph.D. Identification of Hsp90 Cochaperones, Immunophilins, and Client Proteins Heather Desaire, Ph.D. Structural Characterization of Glycoproteins using Mass Spectrometry Susan Egan, Ph.D. Protein-Protein Interactions Required for Transcription Activation by RhaR Jeff Staudinger, Ph.D. Crystallization of Pregnane X Receptor Splice Variants 2002-2004 William Picking, Ph.D. Subversion of Eukaryotic Cell Function by Shigella Anna Zolkiewska, Ph.D Structure and Function of Cell Adhesion Domain of ADAM12 COBRE-PSF Copyright © 2012 Center for Biomedical Research Excellence in Protein Structure and Function Department of Medicinal Chemistry, School of Pharmacy The University of Kansas Contact webmaster with comments about this web site. This project is supported by grants from the National Center for Research Resources (5 P20 RR017708) and the National Institute of General Medical Sciences (8 P20 GM 103420).