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Our Program

KU-NIH Center of Biomedical Research Excellence in Protein Structure and Function (COBRE-PSF).

This NIH-funded Center, which was established in October 2002, is hosted at the University of Kansas (KU). COBRE-PSF has since received a five-year renewal award in May 2008, and a five-year Phase III renewal in August 2014 from the National Institute of General Medical Sciences (P30 GM110761). It is also supported by matching State and University funds. In addition to KU, participating investigators come from the KU School of Medicine, Kansas State University, and Wichita State University.

The objectives of the COBRE program are:

1)   To strengthen institutions’ biomedical research infrastructure through establishment of a thematic multi-disciplinary center,

2)   To continue growing a critical mass of new and continuing investigators focused on the broad theme of protein structure and function, and

 3)  To strengthen our existing Core laboratories by expanding their capabilities and use.

protein preparation

Protein Production Group Core Laboratory
Director Philip Gao is analyzing a sample
using surface plasmon resonance
with a Biacore 3000 housed in the facility.

In pursuit of developing a strong cadre of successful biomedical research faculty, COBRE-PSF provides senior faculty mentors to junior faculty participants, organizes monthly research meetings, and coordinates occasional regional workshops on scientific topics. In this way we are growing a durable Center that will have lasting impact in the state of Kansas. During the past ten years COBRE-PSF has supported 38 junior and senior faculty investigators by providing research support and a professional development program. So far in Phase III the Center has funded 20 Pilot Project Leaders from 15 departments at our four participating universities.

Bio-NMR 800

Bruker Avance 800 MHz NMR

The Center supports three Core Laboratories, each directed by a highly experienced Ph.D. scientist. These facilities perform protein X-ray crystallography, protein purification and production, and bio-molecular NMR detection. Each COBRE-PSF Core Laboratory provides consultation in experimental design, assistance in preparing grant applications and manuscripts, training in specialized research techniques, access to state-of-the-art research equipment (for experienced users), and a menu of research services. The facilities are supported by a combination of COBRE, State, and University funds, and user fees. These laboratories are intended as state-wide resources to serve all researchers in Kansas, but are available to interact with qualified researchers anywhere.

More details about our Center's goals and achievements.

2015-16 COBRE in Protein Structure and Function Brochure

Malott Hall, University of Kansas, Lawrence, KS

 

The Department of Medicinal Chemistry, which serves as the host department for the COBRE in Protein Structure and Function, is in Malott Hall on The University of Kansas campus. The COBRE Core Laboratories (Protein Production, Protein Structure and Bio-NMR) are housed within the Structural Biology Center on KU's West Campus.