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COBRE-PSF Publications, 2002-2017

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2017

Galasiti Kankanamalage, A.C., Kim, Y., Rathnayake, A.D., Damalanka, V.C., Weerawarna, P.M., Doyle, S.T., Alsoudi, A.F., Dissanayake, D.M., Lushington, G.H., Mehzabeen, N., Battaile, K.P., Lovell, S., Chang, K.O., Groutas, W.C. (2017) Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. Eur. J. Med. Chem. 126:502-516. doi: 10.1016/j.ejmech.2016.11.027. Epub 2016 Nov 14. PMID: 27914364. PMC Journal In Process

Kaur, K., Wu, X., Fields, J.K., Johnson, D.K., Lan, L., Pratt, M., Somoza, A.D., Wang, C.C.C., Karanicolas, J., Oakley, B.R., Xu, L., De Guzman, R.N. (2017) The fungal natural product azaphilone-9 binds to HuR and inhibits HuRRNA interaction in vitro. PLoS One. 12(4):e0175471. doi: 10.1371/journal.pone.0175471. eCollection 2017. PMID: 28414767.

Yu, H., Dranchak, P., Li, Z., MacArthur, R., Munson, M.S., Mehzabeen, N., Baird, N.J., Battalie, K.P., Ross, D., Lovell, S., Carlow, C.K., Suga, H., Inglese, J. (2017) Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases. Nat. Commun. 8:14932. doi: 10.1038/ncomms14932. PMID: 28368002.

Yadav, R., Petrunak, E.M., Estrada, D.F., Scott, E.E. (2017) Structural insights into the function of steroidogenic cytochrome P450 17A1. Mol. Cell Endocrinol., 441:68-75. doi: 10.1016/j.mce.2016.08.035. Epub 2016 Aug 24. Review. PMID: 27566228; PMCID: PMC5235955.

Obayashi, E., Luna, R.E., Nagata, T., Martin-Marcos, P., Hiraishi, H., Singh, C.R., Erzberger, J.P., Zhang, F., Arthanari, H., Morris, J., Pellarin, R., Moore, C., Harmon, I., Papadopoulos, E., Yoshida, H., Nasr, M.L., Unzai, S., Thompson, B., Aube, E., Hustak, S., Stengel, F., Dagraca, E., Ananbandam, A., Gao, P., Urano, T., Hinnebusch, A.G., Wagner, G., Asano, K. (2017) Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 Mar 14;18(11):2651-2663. doi: 10.1016/j.celrep.2017.02.052. PMID: 28297669; PMC5382721.

Damalanka, V.C., Kim, Y., Galasiti Kankanamalage, A.C., Lushington, G.H., Mehzabeen, N., Battaile, K.P., Lovell, S., Chang, K.O., Groutas, W.C. (2017) Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease. Eur J Med Chem. 2017 Feb 15;127:41-61. doi: 10.1016/j.ejmech.2016.12.033. Epub 2016 Dec 21. PMID: 28038326; PMC5296247.

2016

Meekins, D.A., Zhang, X., Battaile, K.P., Lovell, S., Michel, K. (2016) 1.45 Å resolution structure of SRPN18 from the malaria vector Anopheles gambiae. Acta Crystallogr. F Struct. Biol. Commun., 72(Pt 12):853-862. PMC5137461 [Available on 2017-12-01]

Kumar, R., Qi, Y., Matsumura, H., Lovell, S., Yao, H., Battaile, K.P., Im, W., Moënne-Loccoz, P., Rivera, M. (2016) Replacing Arginine 33 for Alanine in the Hemophore HasA from Pseudomonas aeruginosa Causes Closure of the H32 Loop in the Apo-Protein. Biochemistry. 55(18):2622-31. doi: 10.1021/acs.biochem.6b00239. Epub 2016 Apr 28. PMID: 27074415.

Li, J., Wehmeyer, G., Lovell, S., Battaile, K.P., Egan, S.M. (2016) 1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae. Acta Crystallogr. F Struct. Biol. Commun., 72(Pt 9):726-31. doi: 10.1107/S2053230X1601298X.  PMC5012214

Budiardjo, S.J., Licknack, T.J., Cory, M.B., Kapros, D., Roy, A., Lovell, S., Douglas, J., Karanicolas, J. (2016) Full and partial agonism of a designed enzyme switch. ACS Synth. Biol., 5(12):1475-1484. PMC5161622  [Available on 2017-12-16]

Weerawarna, P.M., Kim, Y., Galasiti Kankanamalage, A.C., Damalanka, V.C., Lushington, G.H., Alliston, K.R., Mehzabeen, N., Battaile, K.P., Lovell, S., Chang, K.O., Groutas, W.C. (2016)  Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies. Eur. J. Med. Chem. 119:300-18. PMC4916972 [Available on 2017-08-25]

Wahome, N., Cooper, A., Thapa, P., Choudhari, S., Gao, F.P., Volkin, D.B., Middaugh, C.R. (2016) Production of well-characterized virus-like particles in an Escherichia coli-based expression platform for preclinical vaccine assessments. Methods. Mol. Biol., 1404:437-57.  PMID: 27076315  DOI: 10.1007/978-1-4939-3389-1_29  [PubMed - in process]

Gurung, R., Yadav, R., Brungardt, J.G., Orlova, A., Egelman, E.H., Beck, M.R. (2016) Actin polymerization is stimulated by actin cross-linking protein palladin. Biochem. J., 473(4):383-96. doi: 10.1042/BJ20151050. Epub 2015 Nov 25. PMID: 26607837; PMC4912051.

O'Neil, P., Lovell, S., Mehzabeen, N., Battaile, K., Biswas, I. (2016) Crystal structure of histone-like protein from Streptococcus mutans refined to 1.9 Å resolution. Acta Crystallogr. F Struct. Biol. Commun., 72(Pt 4):257-62. doi: 10.1107/S2053230X1600217X.  PMC4822980 [Available on 2017-04-01]

McShan, A.C., Anbanandam, A., Patnaik, S., De Guzman, R.N. (2016) Characterization of the binding of hydroxyindole, indoleacetic acid, and morpholinoaniline to the Salmonella Type III secretion system proteins SipD and SipB. ChemMedChem., 11(9):963-71. PMC5010876 [Available on 2017-05-06]

Wahome, N., Sully, E., Singer, C., Thomas, J.C., Hu, L., Joshi, S.B., Volkin, D.B., Fang, J., Karanicolas, J., Jacobs, D.J., Mantis, N.J., Middaugh, C.R. (2016) Novel ricin subunit antigens with enhanced capacity to elicit toxin-neutralizing antibody responses in mice. J. Pharm. Sci., 105(5):1603-13. PMC4846473 [Available on 2017-05-01]

Jia, K., Cao, R., Hua, D.H., Li, P. (2016) Study of Class I and Class III Polyhydroxyalkanoate (PHA) synthases with substrates containing a modified side chain. Biomacromolecules. 17(4):1477-85. PMC4862738 [Available on 2017-04-11]

Kaur, K., Chatterjee, S., De Guzman, R.N. (2016) Characterization of the Shigella and Salmonella Type III secretion system tip-translocon protein-protein interaction by paramagnetic relaxation enhancement. Chembiochem. 17(8):745-52. PMC4918631 [Available on 2017-04-15]

McNiff, M.L., Haynes, E.P., Dixit, N., Gao, F.P., Laurence, J.S. (2016) Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli. Protein Expr. Purif., 122:64-71. doi: 10.1016/j.pep.2016.02.012. Epub 2016 Feb 23. PMID: 26923061; PMCID: PMC5137367.

Damalanka, V.C., Kim, Y., Alliston, K.R., Weerawarna, P.M., Galasiti Kankanamalage, A.C., Lushington, G.H., Mehzabeen, N., Battaile, K.P., Lovell, S., Chang, K.O., Groutas, W.C. (2016) Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease. J Med Chem. 59(5):1899-913. doi: 10.1021/acs.jmedchem.5b01464. Epub 2016 Feb 8. PMID: 26823007; PMCID: PMC5156532.

Alaofi, A., Farokhi, E., Prasasty, V.D., Anbanandam, A., Kuczera, K., Siahaan, T.J. (2016) Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular dynamics simulations. J. Biomol. Struct. Dyn., 12:1-13. PMC5061580 [Available on 2017-10-12]

Yadav, R., Vattepu, R., Beck, M.R. (2016) Phosphoinositide Binding Inhibits Actin Crosslinking and Polymerization by Palladin. J. Mol. Biol., 428(20):4031-4047. doi: 10.1016/j.jmb.2016.07.018. Epub 2016 Jul 31. PMID: 27487483.

2015

Chaudhury, S., Nordhues, B.A., Kaur, K., Zhang, N., De Guzman RN. (2015) Nuclear Magnetic Resonance Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa. Biochemistry. 54(43):6576-85. PMID: 26451841 PubMed – In Process

Chaudhury, S., de Azevedo Souza, C., Plano, G.V., De Guzman, R.N. (2015) The LcrG Tip Chaperone Protein of the Yersinia pestis Type III Secretion System Is Partially Folded. J Mol. Biol. 2015 Sep 25;427(19):3096-109. PMCID: PMC4579052

Chen, C., Shrestha, R., Jia, K., Gao, P.F.,, Geisbrecht, B.V., Bossmann, S.H., Shi, J., Li, P. (2015) Characterization of Dye-decolorizing Peroxidase (DyP) from Thermomonospora curvata Reveals Unique Catalytic Properties of A-type DyPs. J. Biol. Chem. 290(38):23447-63. PMC4645587

Gowthaman, R., Miller, S.A., Rogers, S., Khowsathit, J., Lan, L., Bai, N., Johnson, D.K., Liu, C., Xu, L., Anbanandam, A., Aubé, J., Roy, A., Karanicolas, J. (2015) DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J. Med. Chem. 2015 Jul 10. [Epub ahead of print]

Barta, M.L., Battaile, K.P., Lovell, S., Hefty, P.S. (2015) Hypothetical protein CT398 (CdsZ) interacts with σ(54) (RpoN)-holoenzyme and the type III secretion export apparatus in Chlamydia trachomatis. Protein Sci. 24(10):1617-32. PMCID: PMC4594661

Galasiti Kankanamalage, A.C., Kim, Y., Weerawarna, P.M., Uy, R.A., Damalanka, V.C., Mandadapu, S.R., Alliston, K.R., Mehzabeen, N., Battaile, K.P., Lovell, S., Chang, K.O., Groutas, W.C. (2015) Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies. J. Med. Chem. 2015 Apr 9;58(7):3144-55. PMCID: PMC4484267

Yao, H., Rui, H., Kumar, R., Eshelman, K., Lovell, S., Battaile, K.P., Im, W., Rivera, M. (2015) Concerted motions networking pores and distant ferroxidase centers enable bacterioferritin function and iron traffic. Biochemistry 54(8):1611-27. PMCID: PMC4496005

Lan, L., Appelman, C., Smith, A.R., Yu, J., Larsen, S., Marquez, R.T., Liu, H., Wu, X., Gao, F.P., Roy, A., Anbanandam, A., Gowthaman, R., Karanicolas, J., De Guzman, R.N., Rogers, S., Aubé, Ji, M., Cohen, R.S., Neufeld, K.L., and Xu, L. (2015) Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol. Oncol. 9(7):1406-20. PMCID: PMC4523432

Wu, X., Lan, L., Wilson, D.M., Marquez, R.T., Tsao, W-C., Gao, P.*, Roy, A., Turner, B., McDonald, P., Tunge, J.A., Rogers, S.A., Dixon, D.A., Aube, J., and Xu, L.* (2015) Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem. Biol. 10(6):1476-84. PMCID: PMC4631057

Awasthi, S., Anbanandam, A., Rodgers, K.K. (2015) Structure of a TLR4-interacting SPA4 peptide. RSC Adv. 5(35):27431-27438. PMCID: PMC4392768

Prasasty, V.D., Krause, M.E., Tambunan, U.S., Anbanandam, A., Laurence, J.S., Siahaan, T.J. (2015)(1)H, (13)C and (15)N backbone assignment of the EC-1 domain of human E-cadherin. Biomol NMR Assign. 9(1):31-5. PMCID: PMC4133310

Wani, P.S., Rowland, M.A., Ondracek, A., Deeds, E.J., Roelofs, J. (2015) Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association. Nat. Commun. 6:6384. PMCID: PMC4380239

Zhang, X., Meekins, D.A., An, C., Zolkiewski, M., Battaile, K.P., Kanost, M.R., Lovell, S., Michel, K. (2015) Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae. J. Biol. Chem. 290(5): 2946-56. PMCID: PMC4317006

Kemege, K.E., Hickey, J.M., Barta, M.L., Wickstrum, J., Balwalli, N., Lovell, S., Battaile, K.P., Hefty, P.S. (2015) Chlamydia trachomatis protein CT009 is a structural and functional homolog to the key morphogenesis component RodZ and interacts with division septal plane localized MreB. Mol. Microbiol. 95(3): 365-82. PMCID: PMC4485377

2014

Barta, M.L., Hickey, J.M., Anbanandam, A., Dyer, K., Hammel, M., Hefty, P.S. (2014) Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding. PLoS One. 9(3):e91760. PMCID: PMC3960148

Vattepu, R., Yadav, R., Beck, M.R. (2014) Actin-induced dimerization of palladin promotes actin-bundling. Protein Sci. 24(1): 70-80. PMCID: PMC4282413

Petrunak, E.M., DeVore, N.M., Porubsky, P.R., Scott, E.E. (2014) Structures of human steroidogenic cytochrome P450 17A1 with substrates. J. Biol. Chem. 289(47): 32952-64. PMCID: PMC4239641

Barta, M.L., Thomas, K., Yuan, H., Lovell, S., Battaile, K.P., Schramm, V.L., Hefty, P.S. (2014) Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway. J. Biol. Chem. 289(46):32214-29. PMCID: PMC4231696

Borrego-Diaz, E., Powers, B.C., Azizov, V., Lovell, S., Reyes, R., Chapman, B., Tawfik, O., McGregor, D., Diaz, F.J., Wang, X., Veldhuizen, P.V. (2014) A potential regulatory loop between Lin28B:miR 212 in androgen-independent prostate cancer. Int. J. Oncol. 45(6):2421-9. PMCID: PMC4215582

Naik, S., Kumru, O.S., Cullom, M., Telikepalli, S.N., Lindboe, E., Roop, T.L., Joshi, S.B., Amin, D., Gao, P., Middaugh, C.R., Volkin, D.B., Fisher, M.T. (2014) Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Sci. 23(10):1461-78. PMCID: PMC4287005

Valasani, K.R., Carlson, E.A., Battaile, K.P., Bisson, A., Wang, C., Lovell, S., ShiDu Yan S. (2014) High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules. Acta Crystallogr. F Struct. Biol. Commun. 70(Pt 6):717-22. PMCID: PMC4051522

Singh, C.R., Lovell, S., Mehzabeen, N., Chowdhury, W.Q., Geanes, E.S., Battaile, K.P., Roelofs, J. (2014) 1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain. Acta Crystallogr. F Struct. Biol. Commun. 70(Pt 4):418-23. PMCID: PMC3976055

Moise, A.R., Al-Babili, S., Wurtzel, E.T. (2014) Mechanistic aspects of carotenoid biosynthesis. Chem Rev. 114(1):164-93. PMCID: PMC3898671

Estrada, D.F., Skinner, A.L., Laurence, J.S., Scott, E.E. (2014) Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5. J. Biol. Chem. 289(20): 14310-20. PMCID: PMC4022897

Chadegani, F., Lovell, S., Mullangi, V., Miyagi, M., Battaile, K.P., Bann, J.G. (2014) (19)F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability. Biochemistry 53(4):690-701. PMCID: PMC3985773

2013

Hiraishi, H., Shin, B.S., Udagawa, T., Nemoto, N., Chowdhury, W., Graham, J., Cox, C., Reid, M., Brown, S.J., Asano, K.  (2013) Interaction between 25S rRNA A-loop and eIF5B promotes subunit joining and insures stringent AUG selection. J. Mol. Cell Biol.July 8: doi:10.1128/MCB.00771-13 

Walsh, A.A., Szklarz, G.D., Scott, EE.(2013)  Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J. Biol. Chem. 288(18):12932-43. PMC3642336

Eastlund, A., Malik, S.S., Fischer, C.J.(2013) Kinetic mechanism of DNA translocation by the RSC molecular motor. Arch. Biochem. Biophys. 532(2):73-83. doi: 10.1016/j.abb.2013.01.011.  PMC3609899

Holyoak, T., Zhang, B., Deng, J., Tang, Q., Prasannan, C.B., Fenton, A.W. (2013) Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase. Biochemistry  52(3):466-76. doi: 10.1021/bi301341r. Epub 2013 Jan 11. PMC3572911

Park, S.,  Li, X., Kim, H.M.,  Singh, C.R., Tian, G.,  Hoyt, M.A.,  Lovell, S., Battaile, K.P.,  Zolkiewski, M., Coffino, P.,  Roelofs, J.,  Cheng, Y., Finley, D. (2013) Reconfiguration of the proteasome during chaperone-mediated assembly. Nature  497(7450):512-6. PMC3687086

Kumar, R., Lovell, S., Matsumura, H., Battaile, K. P., Moenne-Loccoz, P., Rivera, M.(2013) The Hemophore HasA from Yersinia pestis (HasAyp) Coorinates Hemin with a Single Residue, Tyr75, and with Minimal Conformational Change. Biochemistry 52(16):2705-7.  PMCID in process

Thomas, J.C., O’Hara, J.M., Hu, L., Gao, F.P., Joshi, S.B., Volkin, D.B., Brey, R.N., Fang, J., Karanicolas, J., Mantis, N.J., Middaugh, C.R. (2013) Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Hum. Vaccin. Immunother. 9(4): 1-9.  [PubMed - as supplied by publisher]

Jo, S., Im, W. (2013) Glycan fragment database: A database of PDB-based glycan 3D structures. Nucleic Acids Res. 41(D1):D470-4. doi: 10.1093/nar/gks987.  PMC353121

Xia, Y., DiPrimio, N., Keppel, T.R., Vo, B., Fraser, K., Battaile, K.P., Egan, C., Bystroff, C., Lovell, S., Weis, D.D., Anderson, J.C., Karanicolas, J. (2013) The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation. J. Am. Chem. Soc. 135(50):18840-9. PMCID: PMC3919134

Barta, M.L., Hickey, J., Kemege, K.E., Lovell, S., Battaile, K.P., Hefty, P.S. (2013) Structure of CT584 from Chlamydia trachomatis refined to 3.05 Å resolution. Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun. 69(Pt 11):1196-201. PMCID: PMC3818032

Billings, S.E., Pierzchalski, K., Butler Tjaden, N.E., Pang, X.Y., Trainor, P.A., Kane, M.A., Moise, A.R. (2013) The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 27(12):4877-89. PMCID: PMC3834788

De La Mota-Peynado, A., Lee, S.Y., Pierce, B.M., Wani, P., Singh, C.R., Roelofs, J. (2013) The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome. J. Biol. Chem. 288(41):29467-81. PMCID: PMC3795246

Naik, S., Brock, S., Akkaladevi, N., Tally, J., McGinn-Straub, W., Zhang, N., Gao, P., Gogol, E.P., Pentelute, B.L., Collier, R.J., Fisher, M.T. (2013) Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry 52(37):6335-47. PMCID: PMC3790466

Vitale, A., Thorne, N., Lovell, S., Battaile, K.P., Hu, X., Shen, M., D'Auria, S., Auld, D.S. (2013) Physicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum. PLoS One. 8(6):e63828. PMCID: PMC3673990

Chaudhury, S., Battaile, K.P., Lovell, S., Plano, G.V., De Guzman, R.N. (2013) Structure of the Yersinia pestis tip protein LcrV refined to 1.65 Å resolution. Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun. 69(Pt 5):477-81. PMCID: PMC3660882

2012

Takahashi, D., Hiromasa, Y., Kim, Y., Anbanandam, A., Yao, X., Chang, K.O., Prakash, O. (2012) Structural and dynamics characterization of norovirus protease. Protein Sci. 22(3):347-57. PMC3595464

Bann, J.G.(2012) Anthrax toxin protective antigen: Insights into molecular switching from prepore to pore. Protein Sci. 21(1): 1-12. PMC3323776 

Hu, L., Joshi, S.B., Andra, K.K., Thakkar, S.V., Volkin, D.B., Bann, J.G., Middaugh, C.R. (2012) Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. J. Pharm. Sci.  101(11):4118-28. PMID: 22911632  (PubMed – in process)

Rajapaksha, M., Lovell, S., Janowiak, B.E., Andra, K.K., Battaile, K.P., Bann, J.G. (2012) pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci.  21(10):1467-80. PMC3323776

Panja, A., Eichhorn, D.M.(2012) Mono- and Di-nuclear nickel(II) complexes with mixed N/S-donor ligands: Syntheses, structures and physical properties. Inorganica Chimica Acta  391: 88-92.2012 (Not indexed by PubMed)

Fischer, C.J., Tomko, E.J., Wu, C.G., Lohman, T.M.(2012) Fluorescence methods to study DNA translocation and unwinding kinetics by nucleic acid motors. Methods Mol. Biol. 875:85-104. NIMSID 493824

Naik, S., Zhang, N., Gao, F.P., Fisher, M.T.(2012) On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseases, Curr. Top. Med. Chem. 12(22):2504-22.  PMID: 23339304  [PubMed - in process]

Chang, K.-O., Takahashi, D., Prakash, O., Kim, Y. (2012) Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Virology 423(2): 125-133. PMC3259199

Johnson, T.A., Holyoak, T. (2012) The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry  51(47): 9547-59. PMC3525453

Lee, H.S., Jo, S., Lim, H.S., Im, W.(2012) Application of binding free energy calculations to prediction of binding modes and affinities of MDM2 and MDMX inhibitors. J. Chem. Inf. Model  52:1821−1832.  PMC3480999

Deckert, K., Budiardjo, S.J., Brunner, L.C., Lovell, S.W., Karanicolas, J.(2012) Designing allosteric control into enzymes by chemical rescue structure.  JACS 134(24):10055-60. PMC3381609

Ciaccio, N.A., Reynolds, T.S., Middaugh, C.R., Laurence, J.S. (2012)  Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5). Mol. Pharm.  9(11):3190-9. PMC3535187

Krause, M.E., Martin, T.T., Laurence, J.S. (2012) Mapping site-specific changes that affect stability of the N-terminal domain of calmodulin. Mol. Pharm. 9(4):734-43. PMC3323289

Kim. Y., Lovell. S., Tiew, K.C., Mandadapu, S.R., Alliston, K.R., Battaile, K.P., Groutas, W.C., Chang, K.O. (2012) Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J. Virol. 86(21):11754-62. PMC3486288

Park, K.T., Wu, W., Lovell, S., Lutkenhaus, J.(2012) Mechanism of the asymmetric activation of the MinD ATPase by MinE. Mol. Microbiol. 85(2):271-81. PMC3376909

Thorne, N., Shen, M., Lea, W.A., Simeonov, A., Lovell, S., Auld, D.S., Inglese, J.(2012) Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem. Biol. 19(8):1060-72. PMC3449281

An, C., Hiromasa, Y., Zhang, X., Lovell, S., Zolkiewski, M., Tomich, J.M., Michel, K. (2012) Biochemical characterization of Anopheles gambiae SRPN6, a malaria parasite invasion marker in mosquitoes. PLoS One 7(11):e48689.  PMC3494705

Gulley, M.M., Zhang, X., Michel, K. (2012) The roles of serpins in mosquito immunology and physiology. J. Insect Physiol. pii: S0022-1910 (12) 00224-7. doi: 10.1016/j.jinsphys.2012.08.015.  PMC3560325

Pang, X.Y., Cao, J., Addington, L., Lovell, S.*, Battaile, K.P., Zhang, N.*, Rao, J.L., Dennis, E.A., Moise, A.R.(2012) Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J. Biol. Chem. 287(42):35260-74.  PMC3471684

Yao, H., Wang, Y., Lovell, S., Kumar, R., Ruvinsky, A.M., Battaile, K.P., Vakser, I.A., Rivera, M. (2012) The structure of the BfrB-Bfd complex reveals protein-protein interactions enabling iron release from bacterioferritin. J. Am. Chem. Soc. 134(32):13470-81.  PMC3428730

DeVore, N.M., Scott, E.E. (2012) Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature  482(7383):116-9. PMC3323776

Devore, N.M., Meneely, K.M., Bart, A.G., Stephens, E.S., Battaile, K.P., Scott, E.E. (2012) Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. FEBS J.  279(9):1621-31. PMC3572744

DeVore, N.M., Scott, E.E.,(2012) Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. J. Biol. Chem. 287(32):26576-85. PMC3410998

Meinhardt, S., Manley, M.W., Becker, N.A., Hessman, J.A., Maher, L.J., Swint-Kruse, L. (2012) Novel insights from hybrid Lacl/GalR proteins: Family-wide functional attributes and biologically significant variation in transception repression. Nucleic Acids Res.   40(21): 11139-11154. PMC3505978

Takahashi, D., Kim. Y., Chang, K.-O., Anbanandam, A., Prakash, O. (2012) Backbone and side-chain 1H, 15N, and 13C resonance assignments of Norwalk virus protease. Biomol. NMR Assign.  6(1):19-21.  PMID: 21647610  [PubMed - indexed for MEDLINE]

 

2011

Priyadarshi, A., Tang, L. (2011) Crystallization and preliminary crystallographic analysis of the type III secretion translocator chaperone SicA from Salmonella enterica, Acta Crystal. Sect F; Structural Biology and Crystallization Communications F66: 1533-1535.

Andra, K.K., Bullinger, J.C., Bann, J.G., Eichhorn, D.M. (2011) 2-Fluoro-I-histidine. Acta Cyrstallogr. Sect. E. Struct. Rep. 66(Pt. 11):o2713.

Parthasarathy, S. Altuve, A., Terzyan, S., Zhang, X.-J., Kuczera, D., Rivera, M., Benson, D.R. (2011) Accommodating a non conservative internal mutation by water-mediated hydropgen bonding between beta-sheet strands: A comparison of human and rat type B (mitochondrial) cytochrome beta-five. Biochemistry 50: 5544-5554.

An, C., Lovell, S.W., Kanost, M.R., Battaile, K.P., Michel, K. (2011) Crystal structure of native Anopheles gambiae Serpin-2, a negative regulator of melanization in mosquitoes, Proteins, 1999-2003.

Hickey, J.M., Weldon, L., Hefty, P.S. (2011) The Atypical OmpR/PhoB Response Regulator ChxR from Chlamydia trachomatis Forms Homodimers In Vivo and Binds a Direct Repeat of Nucleotide Sequences. J. Bacteriol. 193(2):389-98. PMID21057008; PMC3019824

Hickey, J.M., Lovell, S., Battaile, K.P., Hu, L., Middaugh, C.R., Hefty, P.S. (2011) The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unqiue within the OmpR/PhoB subfamily. J. Biol. Chem. 2011 286(37): 32606-16.

Panja, A., Campana, C., Leavitt, C., Van Stipdonk, M.J., and Eichhorn, D.M. (2011) Iron and cobalt complexes of 2,6-diacetylpyridine-bis(R-thiosemicarbazone) (R+H, phenyl) showing unprecedented ligand deviation from planarity, Inorganica Chim Acta, 362(4): 1348-1354.

Park, K.-T., Wu, W., Battaile, K.P., Lovell, S.W., Holyoak, T., Lutkenhaus, J. (2011) The min oscillator uses mind-dependent conformational changes in mine to spatially regulate cytokinesis. Cell 146: 396-407.

Wu, W., Park, K.-T., Holyoak, T., Lutkenhaus, J., (2011) Determination of the structure of the MinD-ATP complex reveals the orientaiton of MinD on the membrane and the relative location of the binding sites for MinE and Min C. Molecular Microbiolog 79 (6): 1515-1528.

Yao, H., Jepkorir, G., Lovell, S.W., Nama, P.V., Weeratunga, S., Battaile, K.P., Rivera, M. (2011) Two distinct ferritin-like molecules in Pseudomonas aeruginosa: The product of the bfrA gene is a bacterial ferritin (FtnA) and not a bacterioferritin (Bfr). Biochemistry 50: 5236-5248.

An, C., Budd, A., Kanost, M.R., Michel, K. (2011) Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes. Cell. Mol. Life Sci. 68: 1929-1939.

Estrada, D.F., De Guzman, R.N. (2011) Structural characterization of the Crimean-Congo hemorrhagic fever virus GN tail provides insight into virus assembly. J. Biol. Chem. 286 (24): 21678-28686.

Lee, S. Y.-C., De La Mota-Peynado A., Roelofs, J. (2011) Loss of Rpt5 interactions with the core particle and Nas2 causes the formation of faulty proteasomes that are inhibited by Ecm29. J. Biol. Chem. 286 (42): 36641-36651.

Lee, K.I., Jo, S., Rui, H., Egworlf, B., Roux, B., Pastor, R.W., Im, W. (2011) Web interface for brownian dynamics simulation ion transport and its applications to beta-barrel pores. J. Comp. Chem.DOI: 10.1002/jcc.21952. (331-339).

Jo, S., Song, K.C., Desaire, H., MacKerell, Jr., A.D., Im, W. (2011) Glycan Reader: Automated sugar identification and simulation preparation for carbohydates and glycoproteins. 32(14): 3135-3141.

Cruz, P.G., Auld, D.S., Schultz, P.J., Lovell, S.W., Battaile, K.P., MacAuthur, R., Shen, M., Tamayo-Castillo, G., Ingelese, J., Sherman, D.H. (2011) Titration-based screening for evaluation of natural product extracts: Identification of an aspulvinone family of Luciferase inhibitors. Chem & Biol. 18: 1442-1452.

Kemege, K.E., Hickey, J.M., Lovell, S., Battaile, K.P., Zhang, Y., Hefty, P.S. (2011) Ab Initio structural modeling of and expereimental validation for Chlamydia trachomatis protein CT296 reveal structural similarity to Fe(II) 2-oxoglutarate-dependent enzymes. J. Bacteriology 193(23): 6517-6528. DOI: 10.1128/JB.05488-11.

Chatterjee S., Zhong, D., Nordhues, B.A., Battaile, K.P., Lovell, S., De Guzman, R.N. (2011) The crystal structures of the Salmonella type II secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci. 20(1): 75-86.

Malik, S.S., Rich,E., Viswanathan, R., Cairns B.R., Fischer, C.J. (2011) Allosteric interactions of DNA and nucleotides with S. cerevisiae RSC. Biochemistry. 50(37):7881-90.

Timothy P. Day Diptesh Sil Nikunj M. Shukla Asokan Anbanandam Victor W. Day and Sunil A. David. (2011) Imbuing Aqueous Solubility to Amphotericin B and Nystatin with a Vitamin.
molecular pharmaceutics Mol. Pharm. 8(1): 297-301.

Zimmerman, J.R., Smucker, B.W., Dain, R.P., Van Stipdonk, M.J., Eichhorn, D.M. (2011) Tridentate N(2)S ligand from 2,2'-dithiodibenzaldehyde and N,N-dimethylethylenediamine: Synthesis, structure, and charactierziation of a Ni(II) complex with relevance to Ni Superoxide Dismutase. Inorganica Chim Acta. 373(1): 54-61.

Nti-Addae, K.W., Laurence, J.S., Skinner, A.L., Stella, V.J. (2011) .Reversion of sulfenamide prodrugs in the presence of free thiol-containing proteins. J Pharm Sci. 100(7):3023-7. doi: 10.1002/jps.22505. Epub 2011 Feb 3.

 

2010

Xia, Z., Chibnik, L.B., Glanz, B.I., Liguori, M., Shulman, J.M., Tran, D., Khoury, S.J., Chitnis, T., Holyoak, T., Weiner, H.L., Guttmann, C.R.G., De Jager, P.L. (2010) A putative Alzheimer’s Disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. ;5(11):e14169. PMID: 21152065

Auld, D.S., Lovell, S., Thorne, N., Lea, W.A., Maloney, D.J., Shen, M., Rai, G., Battaile, K.P., Thomas, C.J., Simeonov, A., Hanzlik, R.P., Inglese, J. (2010) Molecular basis for the high-affinity binding and stabilization of fireflyluciferase by PTC124.Proc Natl Acad Sci U S A. 107(11):4878-83. PMID20194791; PMC2841876

Deng, B., Parthasarathy, S., Wang, W., Gibney, B.R., Battaile, K.P., Lovell, S., Benson, D,R., Zhu, H. (2010) Study of the individual cytochrome b5 and cytochrome b5 reductase domains ofNcb5or reveals a unique heme pocket and a possible role of the CS domain.J Biol Chem. 285(39):30181-91. PMID20630863; PMC2943328

Fenton, A.W., Johnson, T.A., Holyoak, T. (2010) The pyruvate kinase model system, a cautionary tale for the use of osmolyteperturbations to support conformational equilibria in allostery. Protein Sci. 19(9):1796-800. PMID20629175; PMC2975142

Jepkorir, G., Rodriguez, J.C., Rui, H., Im, W., Lovell, S., Battaile, K.P., Alontaga, A.Y.,Yukl E.T., Moanne-Loccoz, P., Rivera, M. (2010) Structural, NMR spectroscopic, and computational investigation of hemin loading in thehemophore HasAp from Pseudomonas aeruginosa. J. Am. Chem. Soc. 132(28):9857-72. PMID20572666; PMC2948407

Jiang, L., Fang, J., Moore, D.S., Gogichaeva, N.V., Galeva, N.A., Michaelis, M.L., Zaidi, A. (2010) Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis.Neurobiol Aging. 31(12):2146-59. PMID19118924; PMC2904836

Johnson, T.A., Holyoak, T. (2010) Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalyticfidelity. Biochemistry. 49(25):5176-87. PMID20476774; PMC2893389

Khaki, A.R., Field, C., Malik, S., Niedziela-Majka, A., Leavitt, S.A., Wang, R., Hung, M., Sakowicz, R., Brendza, K.M., Fischer, C.J. (2010) The macroscopic rate of nucleicacid translocation by hepatitis C virushelicase NS3h is dependent on both sugar and base moieties.J Mol Biol. 400(3):354-78. PMID20451531; PMC2902667

Matlock, D.L., Yeruva, L., Byrd, A.K., Mackintosh, S.G., Langston, C., Brown, C., Cameron, C.E., Fischer, C.J., Raney, K.D. (2010) Investigation of translocation, DNA unwinding, and protein displacement byNS3h, the helicase domain from the hepatitis C virus helicase. Biochemistry. 49(10):2097-109. PMID20108974; PMC2853022

Mueller, A.K., Kohlhepp, F., Hammerschmidt, C., Michel, K. (2010) Invasion of mosquito salivary glands by malaria parasites: prerequisites anddefense strategies.Int J Parasitol. 40(11):1229-35. PMID20621627; PMC2916662

Porubsky, P.R., Battaile, K.P., Scott, E.E. (2010) Human cytochrome P450 2E1 structures with fatty acid analogs reveal apreviously unobserved binding mode.J Biol Chem. 285(29):22282-90. PMID20463018; PMC2903405

Rathinavelan, T., Tang, C., De Guzman, R.N. (2010) Characterization of the interaction between the Salmonella type III secretionsystem tip protein SipD and the needle protein PrgI by paramagnetic relaxation enhancement. J Biol Chem. PMID21138848

Rathinavelan, T., Zhang, L., Picking, W.L., Weis, D.D., De Guzman, R.N., Im, W. (2010) A repulsive electrostatic mechanism for protein export through the type III secretion apparatus.Biophys J. 98(3):452-61. PMID20141759; PMC2814197

Reed, T., Lushington, G.H., Xia, Y., Hirakawa, H., Travis, D.M., Mure, M., Scott, E.E., Limburg, J. (2010) Crystal structure of histamine dehydrogenase from Nocardioides simplex.J Biol Chem. 285(33):25782-91. PMID20538584; PMC2919140

Tomko, E.J., Fischer, C.J., Lohman, T.M. (2010) Ensemble methods for monitoring enzyme translocation along single strandednucleic acids.Methods. 51(3):269-76. PMID20371288; PMC2900532

Weeratunga, S.K., Lovell, S., Yao, H., Battaile, K.P., Fischer, C.J., Gee, C.E., Rivera, M. (2010) Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest agating mechanism for iron uptake via the ferroxidase center .Biochemistry. 49(6):1160-75. PMID20067302; PMC2852880

Wimalasena, D.S., Janowiak, B.E., Lovell, S., Miyagi, M., Sun, J., Zhou, H., Hajduch, J., Pooput, C., Kirk, K.L., Battaile, K.P., Bann, J.G. (2010) Evidence that histidine protonation of receptor-bound anthrax protectiveantigen is a trigger for pore formation.Biochemistry. 49(33):6973-83. PMID20672855; PMC2924283

Zhao, H., Finch, C.J., Sequeira, R.D., Johnson, B.A., Johnson, J.E., Casjens, S.R., Tang, L. (2010) Crystal structure of the DNA-recognition component of the bacterial virus Sf6genome-packaging machine. Proc. Natl. Acad. Sci. U S A. 107(5):1971-6.

 

2009

Carlson, G.M., Holyoak, T. (2009) Structural insights into the mechanism of phosphoenolpyruvate carboxykinase catalysis. J. Biol. Chem. 284 (40): 27037-41

Hickey, J.M., Hefty, P.S., Lamb, A.L. (2009) Expression, purification, crystallization and preliminary X-ray analysis of theDNA-binding domain of a Chlamydia trachomatis OmpR/PhoB-subfamily responseregulator homolog, ChxR. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 8): 791-4.

Johnson, T.A., Qiu, J., Plaut, A.G., Holyoak, T. (2009) Active-site gating regulates 0036 substrate selectivity in a chymotrypsin-likeserine protease the structure of haemophilus influenzae immunoglobulin A1protease. J. Mol. Biol. 389(3): 559-74.

Meneely, K.M., Barr, E.W., Bollinger, J.M. Jr, Lamb, A.L. (2009) Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: substrate triggering of O2 addition but not flavin reduction. Biochemistry 48 (20): 4371-6

Rajapaksha, M., Eichler, J.F., Hajduch, J., Anderson, D.E., Kirk, K.L., Bann, J.G. (2009) Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR. Protein Sci. 18 (1):17-23

Rui, H., Lee, J., Im, W. (2009) Comparative molecular dynamics simulation studies of protegrin-1 monomer anddimer in two different lipid bilayers.Biophys. J. 97(3):787-95.

Skinner, A.L., Laurence, J.S. (2009) 1H, 15N, 13C resonance assignments of the reduced and active form of human Protein Tyrosine Phosphatase, PRL-1. Biomol. NMR Assign. 3(1):61-5

Skinner, A.L., Vartia, A.A., Williams, T.D., Laurence, J.S. (2009) Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Biochemistry 48 (20): 4262-72

Weeratunga, S.K., Gee, C.E., Lovell, S., Zeng, Y., Woodin, C.L., Rivera, M. (2009) Binding of Pseudomonas aeruginosa apobacterioferritin-associated ferredoxin to bacterioferritin B promotes heme mediation of electron delivery and mobilization of core mineral iron. Biochemistry 48 (31): 7420-31

Williams, A.S., Lovell, S., Anbanandam, A., El-Chami, R., Bann, J.G. (2009) Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH. Protein Sci. 18 (11):2277-86

Zaidi, A., Fernandes, D., Bean, J.L., Michaelis, M.L. (2009) Effects of paraquat-induced 0001 oxidative stress on the neuronal plasma membraneCa(2+)-ATPase. Free Radic. Biol. Med. 47(10):1507-14.

Zhao, H., Heroux, A., Sequeira, R.D., Tang, L. (2009) Preliminary crystallographic studies of the regulatory domain of responseregulator YycF from an essential two-component signal transduction system. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65(Pt 7):719-22.

Zhao, H., Tang, L. (2009) Crystallographic characterization of a multidomain histidine protein kinasefrom an essential two-component regulatory system. Acta Crystallogr. Sect. F Struct Biol. Cryst. Commun. 65(Pt 4):346-9.

Ciaccio, N.A., Laurence, J.S. (2009) Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5. Mol. Pharm. 6(4): 1205-1215. PMID: 19435374

Fischer, C.J., Yamada, K., Fitzgerald, D.M. (2009) Kinetic mechanism for single-stranded DNA binding and translocation by Saccharomyces cerevisiae Isw2. Biochemistry 48(13): 2960-8. PMID: 19203228

Katayama, H., McGill, M., Kearns, A., Brzozowski, M., Degner, N., Harnett, B., Kornilayev, B., Matkovic-Calogovic D., Holyoak, T., Calvet, J.P., Gogol, E.P., Seed, J., Fisher, M.T. (2009) Strategies for folding of affinity tagged proteins using GroEL and osmolytes. J. Struct. Funct. Genomics 10:57-66. PMID: 19082872

Thomas, C.A., Talaty, E.R., Bann, J.G. (2009) 3S-fluoroproline as a probe to monitor proline isomerization during protein folding by 19F-NMR. Chem. Communications (Camb). 23: 3366-68. PMID: 19503872

Johnson, T.A., Qiu, J., Plaut, A.G., and Holyoak, T., Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of haemophilus influenzae immunoglobulin A1 protease. J. Mol. Biol. 2009, 389(3):559-74. PMID: 19393662

Ciaccio, N.A., and Laurence, J.S., Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5. Mol. Pharm. (2009) May 28. PMID: 19435374

Skinner, A.L., Vartia, A.A., Williams, T.D., Laurence, J.S. Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Biochemistry (2009) 48(20):4262-72. PMID: 19341304

Swint-Kruse, L., Matthews, K.S., Allostery in the LacI/GalR family: variations on a theme.
Curr. Opin. Microbiol. (2009) 12(2):129-37. PMID: 19269243

 

2008

De Guzman, R.N., Bacterial nanoinjectors, Chemical Biology (Royal Society 0037
of Chemistry), 2008, 3, B81-B88.

Chen, X.W., Han, B., Fang, J., Haasl, R.J., Large-scale Protein-Protein Interaction prediction using novel kernel methods. Int. J. Data Min Bioinform. 2008, 2(2): 145-56. PMID18767352

Ciaccio, N.A., Moreno, M.L., Bauer, R.L., Laurence, J.S., High-yield expression in E. coli and refolding of
the bZIP domain of activating transcription factor 5. Protein Expr. Purif. 2008, 62: 235-43. PMID18718539 PMC2599749

Lee, J., Chen, J., Brooks, C.L. 3rd, Im, W. Application of solid-state NMR restraint potentials in membrane protein modeling. J. Magn. Reson. 2008, 193(1):68-76.

Martin, A., David, V., Laurence, J.S., Schwarz, P,M., Lafer, E.M., Hedge, A.-M., Rowe, P.S. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology, 2008, 149(4): 1757-72. PMID18162525 PMC2276704

Meinhardt, S., Swint-Kruse, L., Experimental identification of specificity determinants in the domain linker of a LacI/GalR protein: bioinformatics-based predictions generate true positives and false
negatives. Proteins, 2008, 73(4): 941-57. PMID18536016 PMC2585155

Miller, M.A., Scott, E.E., Limburg, J., Expression, purification, crystallization and preliminary X-ray studies of a prolyl-4-hydroxylase protein from Bacillus anthracis. Acta Crystallogr. Sect.
F Struct. Biol. Cryst. Commun. 2008, 64(9): 788-91. PMID18765905 PMC2531266

Porubsky, P.R., Meneely, K.M., Scott, E.E. Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J. Biol. Chem. 2008, 283(48): 33698-707. PMID18818195 PMC2586265

Rajapaksha, M., Eichler, J.F., Hajduch, J., Anderson, D.E., Kirk, K.L., and Bann, J.G., Monitoring Anthrax toxin receptor dissociation from the protective antigen by NMR. Protein Science. 2008,18: 17-23. 10.1002/pro.26.

Reed, T.M., Hirakawa, H., Mure, M., Scott, E.E., Limburg, J., Expression, purification, crystallization and
preliminary X-ray studies of histamine dehydrogenase from Nocardioides simplex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008, 64(9): 785-7 PMID18765904 PMC2531280

Rodriguez, J.C., Zeng, Y., Wilks, A., Rivera, M., The hydrogen-bonding network in heme oxygenase also functions as a modulator of enzyme dynamics: chaotic motions upon disrupting the H-bond network in heme oxygenase from Pseudomonas aeruginosa. J. Am. Chem. Soc. 2007, 129(38): 11730-42. PMID17764179

Schlicht, K.E., Michno, N., Smith, B.D., Scott, E.E., Murphy, S.E., Functional characterization of CYP2A13 polymorphisms. Xenobiotica, 2007, 37: 1439-49. PMID17922361

Skinner, A.L., Laurence, J.S., High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands. J. Pharm. Sci., 2008, 97: 4670-95 PMID18351634

Swint-Kruse, L., Fisher, H.F., Enzymatic reaction sequences as coupled multiple traces on a multidimensional landscape. Trends Biochem. Sci. 2008, 33: 104-12. PMID18261912

Taraban, M., Zhan, H., Whitten, A.E., Langley, D.B., Matthews, K.S., Swint-Kruse, L., Trewhella, J., Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein. J. Mol. Biol. 2008, 376(2): 466-81. PMID18164724 PMC2430094

Tarca, A.L., Carey, V.J., Chen, X.-W., Romero, R.R., Sorin, S., Machine learning and its applications to biology. PLoS Comput. Biol. 2007 3(6): e116. PMID17604446 PMC1904382

Wang, Y., Zhang, L., Picking, W.L., Picking, W.D., De Guzman, R.N., Structural dissection of the extracellular moieties of the type III secretion apparatus. Molecular BioSystems, 2008, 4: 1176-1180.

Wang, Y., Ouellette, A.N., Egan, C.W., Rathinavelan, T., Im, W., De Guzman, R.N., Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH. J. Mol. Biol. 2007, 371(5): 1304-14 PMID17617421 PMC1976599

Zhan, H., Taraban, M., Trewhella, J., Swint-Kruse, L., Subdividing repressor function: DNA binding affinity, selectivity, and allostery can be altered by amino acid substitution of nonconserved
residues in a LacI/GalR homologue. Biochemistry, 2008, 47(31): 8058-69. PMID18616293 PMC2561905

Panja, A., Campana, C., Leavitt, C., Van Stipdonk, M.J., and Eichhorn, D.M., Iron and cobalt complexes of 2,6-diacetylpyridine-bis(R-thiosemicarbazone) (R=H, phenyl) showing unprecedented ligand deviation from planarity, Inorg. Chim. Acta. 2008, accepted for publication.

Swint-Kruse, L., Fisher, H.F., Enzymatic reactions sequences as coupled multiple traces on a multidimensional landscape, Trends in Biochem. Sci.. 2008, 33(3): 104-112. PMID: 18261912

Taraban, M., Zhan, H., Whitten, A.E., Langley, D.B., Matthews, K.S., Swint-Kruse L., Trewhella, J., Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein, J. Mol. Biol. 2008, 376(2): 466-81. PMID: 18164724

Bousfield, G.R., Butnev, V.Y., Bidart, J.M., Dalpathado, D., Irungu, J., and Desaire, H., Chromatofocusing fails to separate hFSH isoforms on the basis of glycan structure. Biochemistry2008 , 47(6):1708-20.

 

2007

Taraban, M., Zhan, H., Matthews, K., Swint-Kruse, L., Trewhella, J., Small angle scattering studies of Lacl repressor. Biophysical J. Supplement 2007, 52a: 238-Pos.

Swint-Kruse, L., Zhan, H., Tungtur, A., Meinhardt, S., Functional effects of exchanging domains between homologous proteins are mediated by the linker. Biophysical J. Supplement 2007, 219a: 1027-Pos.

Bousfield, G.R., Butnev, V.Y., Walton, W.J., Nguyen, V.T., Huneidi, J., Singh, V., Kolli, K., Harvey, D.J., Rance, N.E., All-or-none N-Glycosylation in primate follicle-stimulating hormone beta-subunits. Mol. Cell Endocrinol. 2007, 260-262: 40-48. PMID: 17079072

Irungu, J., Go, E.P., Dalpathado, D.S., Desaire, H., Simplification of mass spectral analysis of acidic glycopeptides using GlycoPep ID. Anal. Chem. 2007, 79(8):3065-74. PMID: 17348632

Go, E.P., Rebecchi, K.R., Dalpathado, D.S., Bandu, M.L., Zhang, Y., Desaire, H., GlycoPep DB: a tool for glycopeptide analysis using a "Smart Search". Anal. Chem. 2007, 79(4):1708-13. PMID: 17297977

Kolin, A., Jevtic, V., Swint-Kruse, L., Egan S. M., Linker regions of the RhaS and RhaR proteins. J. Bacteriology 2007, 189(1): 269-271. PMID: 17071764

Tungtur, S., Egan, S.M., Swint-Kruse, L., Functional consequences of exchanging domains between LacI and PurR are mediated by the intervening linker sequence. Proteins: Structure, Function, and Bioinformatics 2007, 68(1):375-88. PMID: 17436321

Stubbs, J.R., Liu, S., Tang, W, Zhou, J., Wang, Y., Yao, X., Quarles, D.L., Role of hyperphosphatemia and 1,25(OH)2D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J. Am. Soc. Nephrol. 2007, 18(7): 2116-24. PMID: 17554146

Liu, S., Quarles, L.D., How fibroblast growth factor 23 work. J. Am. Soc. Nephrol. 2007, 18(6): 1637-1647. (Review) PMID: 17494882

Liu, S., Gupta, A., Quarles, D.L., Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization. Curr. Opin. Nephrol. Hypertens. 2007, 16(4):329-35. (Review) PMID: 17565275

Liu, S., Rowe, P.S., Vierthaler, L., Zhou, J., Quarles, L.D., Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. J. Endocrinol. 2007, 192(1):261-7. PMID: 17210763

Smith, B.D., Sanders, J.L., Porubsky, P.R., Lushington, G.H., Stout, C.D., Scott, E.E., Structure of the human lung cytochrome P450 2A13. J. Biol. Chem. 2007, 282: 17306 - 17313. PMID: 17428784 doi:10.1074/jbc.M702361200

Wilson, C.J., Zhan, H.L., Swint-Kruse, L., Matthews, K.S., Ligand interactions with Lac repressor protein and the repressor-operator complex: The effects of ionization and oligomerization on binding. Biophys. Chem. 2007, 126: 94-105. PMID: 16860458

Wilson, C.J., Zhan, H.L., Swint-Kruse, L., Matthews, K.S., The lactose repressor system: Paradigms for regulation, allosteric behavior, and protein folding. Cell. Mol. Life Sci. 2007, 64: 3-16. PMID: 17103112

Birket, S., Harrington, A.T., Espina, M., Smith, N., Terry, C.M., Darboe, N., Markham, A.P., Middaugh, C.R., Picking, W.L., Middaugh, C.R., Picking, W.D., Preparation and characterization of rranslocator/chaperone complexes and their component proteins from Shigella flexneri. Biochemistry 2007, 46(27): 8128 - 8137. PMID: 17571858

Johnson, S., Roversi, P., Espina, M., Olive, A., Deane, J.E., Birket, S., Field, T., Picking, W.D., Blocker, A.J., Galyov E.E., Picking, W.L., Lea, S.M., Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD. J. Biol. Chem. 2007, 282 (6): 4035-44. PMID: 17077085

Wickstrum, J. R., Kolin, A.D., Jin, J., Fang, J., Egan, S.M., Transcription activation by the DNA-binding domain of the AraC family protein RhaS in the absence of its effector-binding domain, J. Bacteriol. 2007, 189(14): 4984-93. PMID: 17513476

Ansar, S., Burlison, J.A., Hadden, M.K., Yu, X.M., Desino, K.E., Bean, J., Neckers, L., Audus, K.L., Michaelis, M.L., and Blagg, B.S., A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity. Bioorg. Med. Chem. Lett. 2007, 17(7):1984-90. PMID: 17276679

Imormino, R.M., Blagg, B.S.J., Gewirth, D.T., Inhibitory ligands adopt different conformations when bound to Hsp90 or GRP94: Implications for paralog-specific drug design. J. Med. Chem. 2007, in press.

Bishop, S., Burlison, J., Blagg, B.S.J., Hsp90: A novel target for the disruption of multiple signaling cascades. Invited Review for Current Cancer Drug Targets2007, in press.

Tarca, A., Carey, V., Chen, X.-W., Romero, R., Draghici, S., Machine learning and its applications to biology. PLoS Computational Biology 2007, in press.

Chen, X.-W, Han, B., Fang, J., Haasl, R., Large-scale protein-protein interaction prediction using novel kernel methods. International Journal of Data Mining and Bioinformatics 2007, in press.

Stubbs, J.R., Liu, S., Quarles, D.L., Role of fibroblast growth factor 23 (FGF23) in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease. Semin. Dialysis. 2007, 20(4):302-8. PMID: 17635819 [PubMed - in process]

Schlicht, K.E., Michno, N., Smith, B.D., Scott, E.E., and Murphy, S.E., Functional characterization of CYP2A13 polymorphisms, Xenobiotica 2007, in press.

Meinhardt, S., Swint-Kruse, L., Amino acid substitutions at nonconserved positions modify function in transcription repressors engineered from LacI and GalR. J. Mol. Biol. 2007, in press.

Wang, Y., Quellette, A.N., Egan, C.W., Rathinavelan, T., Im, W., De Guzman, R.N., Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH. J. Mol. Biol. 2007, 371(5):1304-14. Epub 2007 Jun 15. PMID: 17617421 [PubMed - in process]

Zhang, L., Wang, Y., Olive, A.J., Smith, N.D., Picking, W.D., De Guzman, R.N., Picking, W.L., Identification of the MxiH needle protein residues responsible for anchoring IpaD to the type III secretion needle tip. J. Biol. Chem. 2007, Sep 7; [Epub ahead of print] PMID: 17827155

Smucker, B.W., Van Stipdonk, M.J., Eichhorn, D.M., Incorporation of thiolate donation using 2,2'-Dithiodibenzaldehyde: Complexes of a pentadentate N2S3 ligand with relevance to the active site of co nitrile hydratase, J. Inorg. Biochem.2007, 101(10):1537-42. Epub 2007 Aug 14. PMID: 17698201

Kim, D.-Y., Calvert, J.G., Chang, K.-O., Holren, K., Kerrigan, M., Rowland, R.R.R., Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndorome virus (PRRSV). Virus Res. 2007, 128(1-2):106-14. Epub 2007 Jun 5. PMID: 17553585 [PubMed - in process]

Martin, A., David, V., Laurence, J.S., Schwarz, P.M., Lafer, E.M., Hedge, A.M, Rowe, P.S., Coordination of a metal ligand by the C-terminus of PRL-1 regulates its phosphatase activity. Endocrinology 2008, 149(4):1757-72. PMID: 18162525

Rodriquez, J.C., Zeng, Y., Wilks, A., Rivera, M., The hydrogen bonding network in heme oxygenase also functions as a modulator of enzyme dynamics: Chaotic motions upon disrupting the H-bond network in heme oxygenase from Pseudomonas aeruginosa, J. Am. Chem. Soc. 2007, 129(38):11730-42.. PMID: 17764179

Bann, J.G., Wimalasena, S., Cramer, J., Kirk, K., Anderson, D., Collier, R., Melnyk, R., Juris, S., Janowiak, B., Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation and translocation, Biochemistry, 2007, 46(51):14928-36. PMID: 18044973

Meneely, K.M., Lamb, A.L., Biochemical characterization of a flavin adenine dinucleotide-dependent monooxygenase, ornithine hydroxylase from Pseudomonas aeruginosa, suggests a novel reaction mechanism. Biochemistry 2007, 46(42):11930-7. PMID: 17900176

 

2006

Avila, C., Hadden, M.K., Ma, Z., Kornilayev, B.A., Ye, Q.Z., Blagg, B.S.J., High-throughput screening for Hsp90 ATPase inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(11): 3005-8. PMID: 16530412

Wang, M., Shen, G., Blagg, B.S.J., Radanamycin, a macrocyclic chimera of radicicol and geldanamycin. Bioorg. Med. Chem. Lett. 2006, 16(9): 2459-62. PMID: 16464590

Blagg, B.S.J., Kerr, T.D., Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. Med. Res. Rev. 2006, 26(3): 310-38. PMID: 16385472

Avila, C., Kornilayev, B.A., Blagg, B.S.J., Development and optimization of a useful assay for determining Hsp90's inherent ATPase activity. Bioorg. Med. Chem. 2006, 14(4):1134-42. PMID: 16213144

Shen, G., Wang, M., Welch, T.R., Blagg, B.S.J., Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90. J. Org. Chem. 2006, 71(20):7618-31. PMID: 16995666

Peng, W., Blagg , B.S.J., A versatile approach toward the ansamycin antibiotics. Org. Lett. 2006, 8(5): 975-8. PMID: 16494488

Bousfield, G.R., Jia, L., Ward, D.N., Gonadotropins: Chemistry and Biosynthesis. In: Neill J.D. (ed) Knobil and Neill: Physiology of Reproduction, 3rd Edition, Elsevier Press, San Diego, CA, 2006, pp. 1581-1634.

Zhang, L., Wang, Y., Picking, W.L., Picking, W.D., De Guzman, R.N., Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei. J. Mol. Biol. 2006, 359(2): 322-30. PMID: 16631790

Bandu, M.L., Desaire, H., The STEP method (Statistical Test of Equivalent Pathways): Application to pharmaceuticals. Analyst 2006, 131: 268-274 (Invited submission). PMID: 16440093

Huang, M., Xie, S.-X., Ma, Z.-Q., Hanzlik, R.P., Ye, Q.Z., Metal mediated inhibition of methionine aminopeptidase by quinolinylsulfonamides. Biochem. Biophys. Res. Commun. 2006, 339: 506 13. PMID: 16300729

Irungu, J., Dalpathado, D.S., Go, E.P., Jiang, H., Ha, H.V., Bousfield, G.R., Desaire, H., Method for characterizing sulfated glycoproteins in a glycosylation site-specific fashion, using ion-pairing and tandem mass spectrometry. Anal. Chem. 2006, 78: 1181-1190. PMID: 16478110

Zaitseva, J., Lu, J., Olechoski, K.L., Lamb, A.L., Two crystal structures of the isochorismate pyruvate lyase from Pseudomonas aeruginosa. J. Biol. Chem. 2006, 281(44): 33441-9. PMID: 16914555

Darboe, N., Kenjale, R., Picking, W.L., Picking, W.D., Middaugh, C.R., Chemical denaturation of MxiH from Shigella and PrgI from Salmonella. Prot. Sci. 2006, 15(3): 543-52. PMID: 16501225

Deane, J.E., Cordes, F.S., Roversi, P., Johnson, S., Kenjale, R., Picking, W.D., Picking, W.L., Lea, S.M., Blocker, A., Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, the subunit of the Shigella flexneri type III secretion system. Acta Crystallogr. (Sect. F Struct. Biol. Cryst. Commun.) 2006, 62: 302-305. PMID: 16511329

Zhan, H., Swint-Kruse, L., Matthews, K.S., Extrinsic interactions dominate helical propensity in coupled binding and folding of lactose repressor protein hinge helix. Biochemistry 2006, 45: 5896-5906. (Designated as “Hot Article” by Biochemistry editors.) PMID: 16669632

Haasl, R.J., Fang, J.W., Mining protein-protein interaction data. Current Bioinformatics 2006, 1-2: 197-205.

Fang, J.W., Dong, Y.H., Lushington, G.H., Ye, Q.Z., Georg, G.I., Support vector machines in HTS data mining: Type I MetAPs inhibition study. J. Biomolecular Screening 2006, 11(2): 138-144. PMID: 16418315

Xie, S.X., Huang, W.J., Ma, Z.Q., Huang, M., Hanzlik, R.P., Ye, Q.Z., Structural analysis of metalloform-selective inhibition of methionine aminopeptidase. Acta Crystallogr. D Biol. Crystallogr. 2006, 62(4): 425-32. PMID: 16552144

Feng, J.Q., Ward, L. M., Liu S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S.I, Zhang, S., Rios, H., Drezner, M.K., Quarles, L.D., Bonewald, L.F., White, K.E., Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 2006, 38(11): 1310-5. PMID: 17033621 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Liu, S., Zhou, J., Tang, W., Jiang, X., Rowe, D.W., Quarles, L.D., Pathogenic role of FGF23 in Hyp mice. Am. J. Physiol. Endocrinol. Metab. 2006, 291(1): E38-49. PMID: 16449303

Liu, S., Tang, W., Zhou, J., Stubbs, J.R., Luo, Q., Pi, M., Quarles, L.D., FGF23 is a counter-regulatory phosphaturic hormone for vitamin D. J. Am. Soc. Nephrol. 2006, 17(5): 1305-1315. PMID: 16597685

Rowe, P.S., Matsumoto, N., Jo, O.D., Shih, R.N., O’Connor, J., Roudier, M.P., Bain, S., Liu, S., Harrison, J., Yanagawa, N., Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin. Bone 2006, 39(4): 773-786. PMID: 16762607

Liu, S., Lu, Y., Xie, Y., Zhou, J., Bondwald, L.F., Quarles, L.D., Feng, J.Q., Elevated levels of fgf23 in dentin matrix protein 1 (Dmp1) null mice potentially explain phenotypic similarities to hyp mice. The 28th Annual Meeting of the American Society of Bone and Mineral Research, Philadelphia, PA. September 2006. J. Bone Miner. Res. 2006, 21 (suppl1): S51, 1191.

Liu, S., Tang, W., Zhou, J., Quarles, L.D., Local osteoblast/osteocyte defect in Hyp mice causes overproduction of fgf23. The 28th Annual Meeting of the American Society of Bone and Mineral Research, Philadelphia, PA. September 2006. J. Bone Miner. Res. 2006, 21 (suppl1): S51, 1192.

Liu, S., Rowe, P.S.N., Vierthaler, L., Zhou, J., Quarles, L.D., Phosphorylated ASARM peptide from MEPE stimulates FGF23 transcription by inhibiting PHEX enzyme activity. ASN Renal Week 2006, San Diego, CA, November 2006. Abstract F-SA-DS532. J. Am. Soc. Nephrol. 2006, 17:687A.

Stubbs J., Liu S., Tang W., Quarles, L.D., Role of hyperphosphatemia and 1,25(OH)2D3 in vascular calcifications and mortality in FGF23 Null Mice. ASN Renal Week 2006, San Diego, CA, November 2006. Abstract SA-PO541. J. Am. Soc. Nephrol. 2006, 17:689A.

Xie, L., Boyle, D., Sanford, D., Scherer, P.E., Pessin, J.E., Mora, S., Intracellular trafficking and secretion of adiponectin is dependent of GGA coated vesicles. J. Biol. Chem. 2006, 281: 7253-7259. PMID: 16407204

Gupte, A., Mora, S., Activation of the Cbl insulin signaling pathway in cardiac muscle; Dysregulation in obesity and diabetes. Biochemical and Biophysical Research Communications 2006, 342(3):751-757. PMID: 16494846

Wu, D., Asiedu, M., Adelstein, R.S., Wei, Q., A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis. Cell Cycle 2006, 5(11): 1234-1239. PMID: 16721066

Galeva, N.A., Jiang, L., Zaidi, A., Michaelis, M.L., Williams, T.D., Processing ESI-MSI data obtained on a Q-TOF mass spectrometer to improve the results of protein analysis. Proceedings of the American Society for Mass Spectrometry, 2006.

Hadden, M.K., Lubbers, D., Blagg, B.S.J., Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site. Curr. Topics Med. Chem.2006, 6(11):1173-82. PMID: 16842154

Harrington, A.T., Darboe, N., Kenjale, R., Picking, W.L., Middaugh, C.R., Birket, S., Picking, W.D., Characterization of the interaction of single tryptophan containing mutants of IpaC from Shigella flexneri with phospholipid membranes. Biochemistry 2006, 45: 626-636. PMID: 16401091

Dalpathado, D.S., Irungu, J., Go, E.P., Nortan, K., Bousfield, G.R., Desaire, H., Comparative glycomics of the glycoprotein Follicle-Stimulating Hormone (FSH): Glycopeptide analysis of isolates from two mammalian species. Biochemistry 2006, 45(28): 8665-8673. PMID: 16834341

Zhang, Y., Jiang, H., Go, E.P., Desaire, H., Distinguishing phosphorylation and sulfation in carbohydrates and glycoproteins using ion-pairing and mass spectrometry. J. Am. Soc. Mass Spectrom. 2006, 17(9): 1282-88. PMID: 16820302

Fang, Y., Pekosz, A., Haynes, L., Nelson, E.A., Rowland, R.R.R., Production and characterization of monoclonal antibodies against the nucleocapsid protein of Sars-CoV. Adv. Exp. Med. Biol. 2006, 581: 153-156. PMID: 17037523

Ding, X., Lichti, K., Kim I., Gonzalez, F.J, Staudinger, J.L., Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J. Biol. Chem. 2006, 281 (36): 26540-51. PMID: 16825189

Johnson, S., Roversi, P., Espina, M., Deane, J.E., Birket, S., Picking, W.D., Blocker, A., Picking, W.L., Lea, S.M., Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 2006, 62(9): 865-8. PMID: 16946465

Staudinger, J.L., Ding, X., Lichti, K., Pregnane X receptor and natural products: Beyond drug-drug interactions. Expert Opin. Drug Metab. Toxicol. 2006 Dec, 2(6):847-857. PMID: 17125405

Yamada, T.T., Komoto, J.J., Saiki, K.K., Konishi, K.K. Takusagawa, F.F., Variation of loop sequence alters stability of cytolethal distending toxin (CDT): Crystal structure of CDT from Actinobacillus actinomycetemcomitans. Protein Sci. 2006, 14(2): 362-372. PMID: 16434747

Blagg, B.S.J., Targeting the Hsp90-mediated protein folding machinery for the treatment of cancer and neurodegenerative diseases. Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #PP360, C330. (COBRE)

Ding, X., Kim, I., Gonzalez, F.J., Staudinger, J.L., Regulation of constitutive androstane receptor and its target genes by fasting, cyclic AMP, hepatocyte nuclear factor 4-alpha and the peroxisome proliferator-activated receptor-gamma-coactivator-protein-1alpha. Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #PP175, C38.

Pham, A.L., Fu, Q., Zolkiewski, M., Bann, J.G., Initial characterization of CooB: A chaperone protein involved in the assembly of CS1 pili. Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #PP289, C286-287.

Duzhak, T., Kornilayev, B., Huang, W., Yamamoto, Y., Kansas COBRE in Protein Structure and Function: From cloning to crystallization through core labs, Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #C3, C2-3.

Smith, B.D., Sanders, J.L., Stout, C.D., Scott, E.E., Structure and function of the human lung cytochrome P450 2A13, principle activator of the major nicotine-derived procarcinogen. Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #PP085, C164.

Smith, B.D., Sanders, J.L., Stout, C.D., Scott, E.E., Human cytochrome P450 2A13: Correlation between a 2.35Å structure and ligand binding, Experimental Biology 2006, San Francisco, CA, FASEB J. 2006, 18: LB511 Suppl.

Zaidi, A., Jiang L, Bean, J.L., Michaelis, M.L., Age-dependent decrease in synaptic membrane Ca2+-ATPase occurs selectively in cholesterol rich microdomains. Proceedings of the National IDeA Symposium of Biomedical Research Excellence 2006, #PP 419, C371.

Fernandes, D., Zaidi, A., Bean, J.L., Michaelis, M.L., RNAi-induced silencing of the plasma membrane Ca2+-ATPase 2 increase the vulnerability of neurons to stimuli that alter intracellular calcium. Free Radical Biology and Medicine 2006, 41: S169.

 

2005

Yu, X.M., Shen, G., Neckers, L., Blake, H., Holzbeierlein, J., Cronk, B., Blagg, B.S., Hsp90 inhibitors identified from a library of novobiocin analogues. J. Am. Chem. Soc. 2005, 127(37): 12778-9. PMID: 16159253

Yu, X.M., Han, H., Blagg, B.S., Synthesis of mono- and dihydroxylated furanoses, pyranoses, and an oxepanose for the preparation of natural product analogue libraries. J. Org. Chem. 2005, 70(14): 5599-605. PMID: 15989342

Shen, G., Blagg, B.S., Radester, a novel inhibitor of the Hsp90 protein folding machinery. Org. Lett. 2005, 7(11): 2157-60. PMID: 15901158

Harvey, D.J., Bousfield, G.R., Differentiation between sulphated and phosphated carbohydrates in low-resolution matrix-assisted laser desorption/ionization mass spectra. Rapid Commun. Mass Spectrom. 2005, 19(2): 287-8. PMID: 15609366

Desaire, H., Mass Spectrometry (Carbohydrate analysis). 2005 Yearbook of Science and Technology. McGraw-Hill, New York, pp. 197-200, 2005.

Jiang, H., Irungu, J., Desaire, H., Enhanced detection of sulfated glycosylation sites in glycoproteins. J. Am. Soc. Mass Spectrom. 2005, 16: 340-348. PMID: 15734327

Dalpathado, D.S., Jiang, H., Kater, M.A., Desaire, H., Reductive amination of carbohydrates using NaBH(OAc)3. Anal. Bioanal. Chem. 2005, 381: 1130-1137. PMID: 15761738

Zhang, Y., Go, E.P., Jiang, H., Desaire, H., A novel mass spectrometric method to distinguish isobaric compounds that are phosphorylated or sulfated using ion-pairing reagents. J. Am. Soc. Mass Spectrom. 2005, 16(11): 1827-1839. PMID: 16185888

Bandu, M.L., Wilson, J., Vachet, R.W., Dalpathado, D.S., Desaire, H., STEP Analysis (Statistical Test of Equivalent Pathways): A new mass spectrometric method for carbohydrates and peptides. Anal. Chem. 2005, 77: 5886-5893. PMID: 16159118

Wickstrum, J.R., Santangelo, T.J., Egan, S.M., Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli. J. Bacteriol. 2005, 187(19): 6708-18. PMID: 16166533

Picking, W.L., Nishroka, H., Hearn, P.D., Blocker, A., Baxter, M.A., Picking, W.D., Structure-function analysis of invasion plasmid antigen D (IpaD) from Shigella flexneri. Infect. Immun. 2005, 73: 1432-1440. PMID: 15731041

Kenjale, R., Wilson, J., Zenk, S.F., Saurya, S., Picking, W.L., Picking, W., Blocker, A., The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus. J. Biol. Chem. 2005, 280: 42929-42937. PMID: 16227202

Cordes, F., Daniell, S., Kenjale, R., Saurya, S., Picking, W.L., Picking, W.D., Booy, F., Lea, S., Blocker, A., Helical packing of needles from functionally altered Shigella type III secretion systems. J. Mol. Biol. 2005, 354: 206-211. PMID: 16243352

Ding, X., Staudinger, J.L., The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. J. Pharmacol. Exp. Ther. 2005, 314(1): 120-7. PMID: 15833898

Ding, X., Staudinger, J.L., Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase. C. Biochem. Pharmacol. 2005, 69(5): 867-73. PMID: 15710363

Ding, X., Staudinger, J.L., Induction of drug metabolism by Forskolin: The role of the pregnane X receptor and the protein kinase a signal transduction pathway. J. Pharmacol. Exp. Ther. 2005, 312(2): 849-56. PMID: 15459237

Yi, H., Gruszczynska-Biegala, J., Wood, D., Zhao, Z., Zolkiewska, A., Cooperation of the metalloprotease, disintegrin, and cysteine-rich domains of ADAM12 during inhibition of myogenic differentiation. J. Biol. Chem. 2005, 280: 23475-23483. PMID: 15849365 http://www.jbc.org/cgi/reprint/280/25/23475

Zhao, Z., Gruszczynska-Biegala, J., Zolkiewska, A., ADP-ribosylation of integrin a7 modulates the binding of integrin a7b1 to laminin. Biochem. J. 2005, 385: 309-317. PMID: 15361073 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Chen, X.-W., Liu, M., Prediction of protein-protein interactions using random decision forest framework. Bioinformatics 2005, 21: 4394-4000. PMID: 16234318 http://bioinformatics.oxfordjournals.org/cgi/reprint/21/24/4394

Marchin, M., Kelly, P.T., Fang, J.W., Tracker: continuous HMMER and BLAST searching. Bioinformatics 2005, 21: 388-389. PMID: 15347577 http://bioinformatics.oxfordjournals.org/cgi/reprint/21/3/388

Gangani, R. A., Silva, D., Hilliard, G.H., Fang, J.W., Macha, S., Davidson, W.S. A three dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading, Biochemistry 2005, 44: 2759-2769. PMID: 15723520

Fang, J.W., Haasl, R.J., Dong, Y.H., Lushington, G.H., Discover protein sequence signatures from protein-protein interaction data. BMC Bioinformatics 2005, 6: 277. PMID: 16305745 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Wang, L., Liu, S., Quarles, L.D., Spurney, R.F., Targeted overexpression of G protein-coupled receptor kinase 2 (GRK2) in osteoblasts promotes bone loss. Am. J. Physiol. Endocrinol. Metab. 2005, 288(4): E826-34. PMID: 15585587

Liu, S., Brown, T.A., Zhou, J., Xiao, Z., Awad, H.A., Guilak, F., Quarles, L.D., Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J. Am. Soc. Nephrol. 2005, 16(6): 1645-53. PMID: 15843468

Xiao, Z., Awad, H.A., Liu, S., Mahlios, J., Zhang, S., Guilak, F., Mayo, M.S., Quarles, L.D., Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Dev. Biol. 2005, 283(2): 345-56. PMID: 15936013

Wu, W.H., Fang, Y., Rowland, R.R., Lawson, S.R., Christopher-Hennings, J., Yoon, K.J., Nelson, E.A., The 2b protein as a minor structural component of PRRSV. Virus Res. 2005, 114(1-2): 177-81. PMID: 16095746

Rowland, R.R., Chauhan, V., Fang, Y., Pekosz, A., Kerrigan, M., Burton, M.D., Intracellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein: absence of nucleolar accumulation during infection and after expression as a recombinant protein in vero cells. J. Virol. 2005, 79: 11507-11512. PMID: 16103202 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Plagemann, P.G.W., Rowland, R.R.R., Cafruny, W.A., Polyclonal Hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. Viral Immunol. 2005, 18(1): 138-47. PMID: 15802958

Agbas, A., Zaidi, A., Michaelis, E.K., Decreased activity and increased aggregation of brain calcineurin during aging. Brain Res. 2005, 1059: 59-71. PMID: 16150427

Lushington, G.H., Zaidi, A., Michaelis, M.L., Theoretically predicted structures of plasma membrane Ca2+-ATPase and their susceptibilities to oxidation. J. Mol. Graph. Model. 2005, 24: 175-185. PMID: 16169758

Osborn, K.D., Zaidi, A., Urbauer, R.J.B., Michaelis, M.L., Johnson, C.K., Single molecule characterization of the dynamics of calmodulin bound tooxidatively modified plasma membrane Ca2+ ATPase. Biochemistry 2005, 44: 11074 81. PMID: 16101291

Alterman, M.A., Kornilayev, B., Duzhak, T., Yakovlev, D., Quantitative analysis of cytochrome p450 isozymes by means of uniqueisozyme specific tryptic peptides: a proteomic approach. Drug Metab. Dispos. 2005, 33: 1399 407. PMID: 15951447 http://dmd.aspetjournals.org/cgi/reprint/33/9/1399

Zaidi, A., Jiang, L., Michaelis, M.L., Age related alterations in Ca2+ regulatory proteins localized in neuronal raft microdomains. Free Radic. Biol. Med. 2005, 39: S132-3 [366].

Esch, S.W., Zaidi, A., Williams, T.D., Age related changes in rat brain sphingolipid profile by ESI MS/MS. Proc. Amer. Soc. Mass Spec. 2005, AO52889.

Gokulrangan, G., Kanski, J., Zaidi, A., Schoneich, C., Proteomic analysis of age related protein nitration in rat cerebellum. AAPS Journal 2005, 7(S2): M1102.

 

2004

Clevenger, R.C., Blagg, B.S., Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide. Org. Lett. 2004, 6(24): 4459-62. PMID: 15548050

Shen, G., Yu, X.M., Blagg, B.S., Syntheses of photolabile novobiocin analogues. Bioorg. Med. Chem. Lett. 2004, 14(23): 5903-6. PMID: 15501066

Yu, X.M., Shen, G., Blagg, B.S.J., Synthesis of (-)-noviose from 2,3-O-isopropylidene-D-erythronolactol. J. Org. Chem. 2004, 69(21): 7375-8. PMID: 15471498

Clevenger, R.C., Raibel, J.M., Peck, A.M., Blagg, B.S.J., Biotinylated geldanamycin. J. Org. Chem. 2004, 69(13): 4375-80. PMID: 15202892

Bousfield, G.R., Butnev, V.Y., Nguyen, V.T., Gray, C.M., Dias, J.A., MacColl, R., Eisele, L., Harvey, D.J., Differential effects of alpha subunit Asparagine56 oligosaccharide structure on equine lutropin and follitropin hybrid conformation and receptor-binding activity. Biochemistry 2004, 43(33): 10817-33. PMID: 15311943

Jiang, H., Butnev, V.Y., Bousfield, G.R., Desaire, H., Glycoprotein profiling by electrospray mass spectrometry. J. Am. Soc. Mass Spectrom. 2004, 15: 750-758. PMID: 15121204

Wickstrum, J.R., Egan, S.M., Amino acid contacts between sigma 70 domain 4 and the transcription activators RhaS and RhaR. J. Bacteriol. 2004, 186(18): 6277-85. PMID: 15342598

Berring, E., Brancato, S., Grant, K., Schaper, E., Kadavil, S., Smagin, H., Hatic II, S.O., Picking, W.D., Serfis, A., Destabilization of phospholipid model membranes by YplA, a phospholipase A2 secreted by Yersinia enterocolitica. Chem. Phys. Lipids 2004, 131: 135-149. PMID: 15351266

Brobst, D.E., Ding, X., Creech, K.L., Goodwin, B., Kelley, B., Staudinger, J.L., Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J. Pharmacol. Exp. Ther. 2004, 310(2): 528-35. PMID: 15075359

Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J.L., Moore, D.D., Strobel, H.W., CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11, Pharmacogenomics J. 2004, 4(2): 91-101. PMID: 14770174

Zhao, Z., Gruszczynska-Biegala, J., Cheuvront, T., Yi, H., von der Mark, H., von der Mark, K., Kaufman, S.J., Zolkiewska, A., Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin? a7b1. Exp. Cell Res. 2004, 298: 28-37. PMID: 15242759

Ye, Q., Xie, S., Huang, M., Huang, W., Lu, J., Ma, Z., Metalloform-selective inhibitors of E. coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor. J. Am. Chem. Soc. 2004, 126: 13940-1. PMID: 15506752

Allen, M.A., Urbauer, R.J. B., Zaidi, A., Williams, T., Urbauer, J.L., Johnson, C.K., Fluorescence labeling, purification, and immobilization of a double cysteine mutant calmodulin fusion protein for single-molecule experiments. Anal. Biochem. 2004, 325: 273-284. PMID: 14751262

Osborn, K.D., Zaidi, A., Mandal, A., Urbauer, R.J.B., Johnson, C.K., Single-molecule dynamics of the calcium-dependent activation of plasma-membrane Ca2+-ATPase by calmodulin. Biophysical J. 2004, 87: 1892-1899. PMID: 15446271 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Dremina, E.S., Sharov, V.S., Kumar, K., Zaidi, A., Michaelis, E.K., Schöneich, C., Antiapoptotic protein Bcl-2 interacts with and destabilizes the sarco/endoplasmic reticulum Ca-ATPase (SERCA). Biochem. J. 2004, 383: 361-370. PMID: 15245329

Osborn, K.D., Bartlett, R.K., Mandal, A., Zaidi, A., Urbauer, R.J.B., Urbauer, J.L., Galeva, N., Williams, T.D., Johnson, C.K., Single-molecule dynamics reveal an altered conformation for the autoinhibitory domain of plasma membrane Ca2+-ATPase bound to oxidatively modified calmodulin. Biochemistry 2004, 43: 12937-12944. PMID: 15461467

Michaelis, M.L., Zaidi, A., Ansar, S., Dobrowsky, R., Age-dependent up-regulation of brain acid-sphingomyelinase in F344/BNF1 rats. Program No. 1017.11. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, October 2004.

Zaidi, A., Cokulrangan, G., Kanski, J., Michaelis, M.L., Schoneich, C., Proteomic strategies in analysis of age-dependent oxidative modifications in brain proteins. Abstract 28.21. ASBMB Annual Meeting and 8th IUBMB Conference, FASEB J. June 2004.

Zaidi, A., Osborn, K., Urbauer, R., Michaelis, M.L., Johnson, C., Single molecule dynamics of the Calmodulin binding domain of oxidatively modified plasma membrane Ca2+-ATPase. Abstract 326. Free Radic. Biol. Med. 2004, 37(1): S112.

2003

Nguyen, V.T., Singh, V., Butnev, V.Y., Gray, C.M., Westfall, S., Davis, J.S., Dias, J.A., Bousfield, G.R., Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide. Mol. Cell. Endocrinol. 2003, 199(1-2): 73-86. PMID: 12581881

Harrington, A.T., Hearn, P.D., Picking, W.L., Barker, J.R., Wessel A., Picking, W.D., Structural characterization of the N-terminus of IpaC from Shigella flexneri. Infect. Immun. 2003, 71: 1255-1264. PMID: 12595440

Anakk, S., Kalsotra, A., Shen, Q., Vu, M.T., Staudinger, J.L., Davies, P.J., Strobel, H.W., Genomic characterization and regulation of CYP3a13: Role of xenobiotics and nuclear receptors. FASEB J. 2003, 17(12): 1736-8. PMID: 12958193

Staudinger, J.L., Madan, A., Carol, K.M., Parkinson, A., Regulation of drug transporter gene expression by nuclear receptors. Drug Metab. Dispos. 2003, 31(5): 523-7. PMID: 12695338

Cao, Y., Zhao, Z., Gruszczynska-Biegala, J., Zolkiewska, A., Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro. Mol. Cel. Biol. 2003, 23: 6725-6738. PMID: 12972593 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid...

Galeva, N., Yakovlev, D., Duzhak, T., Koen, Y.A., Alterman, M.A., Direct identification of cytochrome P250 isozymes by MALDI-TOF based protomic approach. Drug. Metab. Dispos. 2003, 31: 351-355. PMID: 12642458 http://dmd.aspetjournals.org/cgi/reprint/31/4/351

Duzhak, T., Emerson, M.R., Chakrabarty, A., Alterman, M.A., LeVine, S.M., Analysis of protein induction in the CNS of SJL mice with experimental allergic encephalomyelitis by proteomic screening and immunohistochemistry. Cell Mol. Biol. 2003, 49(5): 723-32. PMID: 14528908

Selected COBRE-PSF Presentations, 2002-June 2006

Brian Blagg
Nine invited presentations including:

  • Organizer (with Robert A. Galemmo Jr.) and Speaker at Technical Session on "Geldanamycin and Beyond: Progress toward the Development of HSP90 Inhibitors." American Chemical Society 231st National Mtg., Atlanta, GA, March 2006.
  • Managing the Hsp90-Mediated Protein Folding Process with Small Molecules; American Chemical Society 231st National Mtg., Atlanta, GA, March 2006.
  • Managing the Hsp90-Mediated Protein Folding Process with Small Molecules; presented at Johnson and Johnson Pharmaceuticals, May 2006; Eli Lilly Pharmaceuticals; June 2006, and Notre Dame Univ.; September 2006.

Roberto De Guzman
Two invited presentations:

  • Univ. of Nevada at Reno, Dec. 2005: NMR Studies of Protein Complexes in Transcription and Pathogenesis
  • Kansas State Univ.; Manhattan, KS, March 2006: NMR Studies of Bacterial and Viral Proteins Involved in Pathogenesis

Susan M. Egan

  • Dept. of Biology, Univ. of Missouri-Kansas City, Kansas City, MO; April 2004.

Audrey Lamb

  • Siderophore Production in Pseudomonas aeruginosa. KUMC Dept. of Biochemistry and Molecular Biology (2004).

William Picking
Four Invited presentations including:

  • Picking, W.D.; Molecular and Biochemical Analysis of Type III Secretion System Proteins; Dept. of Microbiol., Univ. of Miami Miller School of Medicine; Miami, FL; 2005.
  • Picking, W.D.; Molecular and Biochemical Analysis of Type III Secretion System Proteins; Dept. of Microbiology, Univ. of Texas at San Antonio Health Sci. Ctr.; San Antonio, TX; 2005.
  • Picking, W.D.; Protein Functions and Structures in Shigella Invasion of Human Cells, Walter Reed Army Inst. for Res. & Naval Res. Ctr.; Silver Spring, MD; 2005.

Emily Scott
Six Invited presentations including:

  • Invited Speaker at 16th Symposium of Microsomes and Drug Oxidations, Budapest, Hungary, September 2006
  • Structure and Function of the Lung Cytochrome P450 2A13, Dept. of Biochemistry, Biophysics, & Molecular Biology, Iowa State Univ., Ames, IA (2006).
  • Structure-Function in Mammalian Cytochromes P450, Dept. of Chem. & Biochem., Oklahoma Univ., Normal, OK (2006).
  • Structural Diversity of Membrane Cytochromes P450: Lessons from Recent Literature, Dept. of Pharmacology, Univ. of Michigan, Ann Arbor, MI (2005).

Jeff Staudinger
Seven invited presentations including:

  • PXR and CAR: Master Regulators of Xenobiotic and Metabolic Homeostasis. Stowers Inst. for Medical Res., Kansas City, MO. June 29, 2005.
  • Co-Regulation of Drug Metabolizing Enzymes and Drug Transporter Proteins by Orphan Nuclear Receptors. Am. Assoc. of Pharm. Scientists (AAPS), Salt Lake City, UT. Oct. 2003.
  • Session Chair and Speaker, Turning ADME On and Off: The Pregnane X Receptor as the Master Switch. Internatl. Soc. for the Study of Xenobiotics (ISSX) Annual Mtg. Topic: Genetically Modified Animals in Absorption,
  • Distribution, Metabolism and Excretion (ADME) Research. Providence, RI. Oct. 2003.
  • Metabolic Considerations in the Action of Herbal Medicines. Am. Soc. for Pharmacol. and Experimental Therapeutics Conf. San Francisco, CA. April 2006.
  • Nuclear Receptors as Drug Targets for Obesity (Plenary Session Co-Chair and Speaker). Internatl. Soc. for the Study of Xenobiotics (ISSX) North American Annual Mtg. Rio Grande, Puerto Rico. Oct. 2006.

James Bann

  • Mechanistic studies of the anthrax protective antigen through fluorine labeling; Third Annual Great Plains Infectious Disease Mtg., Oct. 2005.

Xue-Wen Chen

  • IEEE CIS Technical Committee on Bioinformatics and Bioengineering (2005) Optimized Kernel Machine for Cancer Classification using Gene Expression Data

David Eichhorn
Two invited presentations including:

  • Modeling the Active Sites of Metalloenzymes with Thiolate Coordination; SW Missouri State Univ., Springfield, MO; March 2004.

Jianwen Fang

  • Machine Learning Approaches in QSAR and HTS Data-mining; School of Pharmacy, East China Univ. of Science and Technology; China; May 2005.

Silvia Mora
Two invited presentations, including:

  • Distinct Trafficking Pathways of Adiponedctin and Leptin in Adipocytes (poster); Am. Diabetes Assoc. Annual Mtg.; Washington, D.C.; June 2006.

Robert R.R. Rowland

  • Invited presentation at Midwest Regional Ctr. of Excellence for Biodefense & Emerging Infectious Diseases Research (MRCE) Regional Mtg., St. Louis, Oct. 2004 & 2006

Irina Smirnova
Two invited presentations:

  • Scientific Forum XV Intl. Congress of Cardiovascular Sci.; Molecular mechanisms underlying the arrest of diabetic cardiomyopathy -Studies in rat models of type 1 diabetes; Rio de Janeiro, Brazil; Dec. 2005.
  • Combined Sections Mtg. of Am. Phys. Therapy Assoc.; Metabolic Syndrome: Evidence, Education and Effective Intervention Strategies; San Diego, CA; Feb. 2006.

Asma Zaidi

  • Annual Mtg. of the Red Cell Club, “Oxidative Modification of the Erythrocyte Plasma Membrane Ca2+-ATPase by Hydrogen Peroxide,” Columbia, MO, Nov. 2004.