The recipient of the ISSX North American New Investigator Award in Honor of James Gillette is Emily Scott, Associate Professor in the Department of Medicinal Chemistry at the University of Kansas and a COBRE-PSF member. Scott received her award at the 18th North American Regional ISSX Meeting in Dallas in October 2012
Dr. Scott's supporters cite her as a gifted, innovative, and highly accomplished drug metabolism scientist and structural biologist, an active mentor of graduate students and post-doctoral fellows in her field, and an energetic participant in a variety of national and international professional activities. Her research is focused on obtaining crystal structures of the mammalian P450 enzymes that play an important role in drug metabolism. She has solved multiple P450 and P450-ligand complex structures including those of CYP2A6, CYP2A13 and CYP2E1. This work has resulted in more than 20 publications from her own lab.
She is able to count several significant "firsts" among her research accomplishments, including the first structure of CYP2B4, a close analog of the human enzyme CYP2B6, the first structure of CYP2A13, a human lung P450 that metabolizes nicotine and tobacco-derived carcinogens such as NNK, and the first structure of CYP2E1, an enzyme that underlies the generation of a multitude of chemically reactive and toxic metabolites.
Scott earned her Ph.D., (Biochemistry and Cell Biology) at Rice University in Houston, Texas and her B.S. in Marine Biology at Texas A&M University.