Former COBRE-PSF investigator and KU medicinal chemistry professor Brian Blagg has been named a new Senior Editor of the Journal of Medicinal Chemistry. The Journal is a peer-reviewed scientific journal, published since 1959 by the American Chemical Society. It was originally published as the Journal of Medicinal and Pharmaceutical Chemistry, but changed its name in 1963 to the current title.
Dr. Brian Blagg earned a B.A. in chemistry and environmental studies in 1994 from Sonoma State University and a Ph.D. in organic chemistry in 1999 from the University of Utah. In 2002, Blagg completed an NIH Postdoctoral Fellow at The Scripps Research Institute. Blagg was funded by the COBRE-PSF from 2002-2005 when he joined KU as an assistant professor.
The primary goals for of the Blagg Research Team are to design, synthesize, and evaluate novel inhibitors of the Hsp90 protein folding process. To achieve these goals, they use computer modeling to design new molecules to bind to these ATP binding sites, develop new organic reactions that allow access the desired compounds in a highly efficient manner, and finally, develop assays that are suitable for determining the biological effects of our rationally designed Hsp90 inhibitors. They are engaged in more than 30 collaborative studies with researchers throughout the world.