Core Laboratories Overview
The KU COBRE Center in Protein Structure and Function supports three Core Laboratories, each directed by a highly experienced Ph.D. scientist:
- Protein Production Group
- Protein Structure (X-ray) Laboratory
- Biomolecular NMR laboratory.
Each lab director provides consultation in experimental design, assistance in preparing grant applications and manuscripts, training in specialized research techniques, and access to state-of-the-art equipment (for experienced users). Our services are available to qualified researchers in academia and industry on a fee-for-service basis. A menu of standard research services is available, and multi-lab collaborative projects are common.
Our Fragment Screening Program blends the services of all three core labs to screen our fragment libraries against any protein of interest using STD (Saturation Transfer Difference) NMR, SPR (surface plasmon resonance) or even X-ray crystallography. Our core laboratories also interface effectively with computational and synthetic chemistry service labs to carry a project seamlessly from screening for hits to lead development and improvement.
The COBRE-PSF core laboratories are housed in the 44,000 sq. ft. Delbert M. Shankel Structural Biology Center (SBC) on the KU west campus, which is devoted to advancing biomedical and bioscience research.