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Faculty Investigators

Pilot Project Directors

COBRE Pilot Project Leaders are tenured or tenure-track faculty who are interested in developing a promising new line of research that incorporates a significant emphasis on protein structure and function, and that will take advantage of both the interactivity among Center participants and the Center's Core Labs. Pilot Project Leaders may be junior faculty, returning COBRE Graduates, or more established faculty researchers whose participation will strengthen the center overall. These grants support proposals of high quality in terms of originality, scientific interest, and likelihood of growing into a larger project that will be competitive for funding through the NIH R01 mechanism.

Current Pilot Project Directors

Ryan Altman Ryan Altman(University of Kansas)

Inhibition of Bacterial Resistance Enzymes using Structure-guided Drug Design (2016-2017)
Inhibition of Bacterial Aminoglycoside Resistance Enzymes using a Fragment-based Drug Design Approach (2015-2016)


David DavidoDavid Davido (University of Kansas)

Determination of Protein-Protein Interactions of the HSV-1 ICP0 C-terminal Domain (2016-2017)



 a.=A. Sally Davis (Kansas State University)

Characterization of protease TMPRSS2 and its interaction with influenza A (2016-2017)




Kathrin SchrickKathrin Schrick (Kansas State University)

Ligand-binding and structural studies of the START domain from HD-Zip proteins (2016-2017)



Alexandre ShvartsburgAlexandre Shvartsburg (Wichita State University)

Characterization of histone proteoforms using ion mobility separations (2016-2017)




Michael Zhuo WangMichael Zhuo Wang (University of Kansas)

Expression and Function of CYP5122A1, an Essential Leishmanial Sterol Biosynthesis Enzyme (2016-2017)



Past Pilot Project Directors

 Katsura Asano photoKatsura Asano (Kansas State University)

Molecular basis of control of translational initiation in eukaryotes (2012-2013)


James Bann photoJames Bann (Wichita State University)

Structure and Mechanism of CS1 Pilus Assembly (2005-2007)



Moriah Beck photoMoriah Beck (Wichita State University)

Regulation of palladin structure and function (2014-2015)


Fariba BehbodFariba Behbod (University of Kansas Medical Center)

Role of BCL9 in STAT3 Signaling and DCIS Invasive Progression (2015-2016)


Cory BerklandCory Berkland(University of Kansas)

Antigen-drug Conjugates as Potent Antigen-specific Immunotherapies (2015-2016)


Xue-Wen Chen photoXue-Wen Chen (University of Kansas)

Computational Proteomics: Protein Interaction Prediction (2004-2007)


Jeremy Chien photoJeremy Chien (University of Kansas Medical Center)

Structure and function of RABL3 in paclitaxel resistance (2014-2015)


Roberto de Guzman photoRoberto De Guzman (University of Kansas)

Interactions of Salmonella Needle and Tip Proteins (2008-2010)
Structure and Dynamics of Bacterial Needle Proteins (2005-2007)

David Eichhorn photoDavid Eichhorn (Wichita State University)

Synthesis of Model Complexes for Nitrile Hydratase (2004-2007)


Revathi Govind photoRevathi Govind (Kansas State University)

Structure-function studies on Clostridium difficile anti-sigma factor TcdC (2012-2013)


Scott Hefty photoP. Scott Hefty (University of Kansas)

Structural and functional genomics for Chlamydial hypothetical proteins (2012-2013)


Weijun Huang photoWeijun Huang (University of Kansas)

Structural and Functional Studies on D52 Tumor Proteins from Humans  (2004-2007)


Wonpil photoWonpil Im (University of Kansas)

NMR and Computational Studies of Protein Translocation in Bacterial Needles (2008-2010)


Carey K. JohnsonCarey K. Johnson(University of Kansas)

Tracking Nitric Oxide Synthase Conformations and Dynamics (2015-2016)


John Karanicolas photoJohn Karanicolas (University of Kansas)

Towards Novel Inhibitors of OX40L-OX40: A Dominant Negative Approach (ARRA) (2009-2011)


Audrey Lamb photoAudrey Lamb (University of Kansas)

Structural Analysis of Siderophore Biosynthesis  (2004-2005)


Jed LampeJed Lampe (University of Kansas Medical Center)

Defining the Hydrophobic and Electrostatic Interactions between CYP3A and CYPb5 (2015-2016)



Ping Li photoPing Li (Kansas State University)

Engineering Human NRMT1 for its Substract Profiling (2015-2106)
Expression and purification of an obesity-important enzyme hGOAT in E.coli (2012-2013)



Shiguang Liu photoShiguang Liu (University of Kansas Medical Center)

Identification of Inhibitors and Substrates of Phex (2004-2007)

Robin Maser, Associate Professor, University of Kansas Medical CenterRobin Maser (University of Kansas Medical Center)

Heterotrimeric G Protein Binding by Polycystin-1, an Atypical GPCR (2015-2016)



Kristin Michel photoKristin Michel (Kansas State University)

Structure and Target Protease of Anopheles SRPN6, an Inhibitor of Malaria Parasite Infection (ARRA) (2009-2011)


Alexander Moise photoAlexander Moise (University of Kansas)

Structural Characterization of Lecithin:Retinol Acyltransferase (ARRA) (2009-2011)


Silvia Mora photoSilvia Mora (Kansas State University)

Protein Interactions that Regulate Leptin Secretion (2004-2006)


Jackob Moskovitz, Associate Professor of Pharmacology and Toxicology, University of KansasJackob Moskovitz (University of Kansas)

Effect of Methionine Substitution and Oxidation on the Structure-Function of COMT (2015-2016)



Raymond Perez photoRaymond Perez (University of Kansas Medical Center)

Rational design of SPRY2-Cbl inhibitors as potential anticancer drugs (2014-2015)


Mario Rivera photoMario Rivera (University of Kansas)

A new approach to antimicrobial discovery: Design protein/protein interaction modulators to perturb bacterial iron metabolism(2014-2015)
Dynamics and Interactions in the Release of Iron Stored in Bacterioferritin (2010-2012)
Mechanisms of Heme Capture by the Hemophore Secreted by Pseudomonas aeruginosa (2008)

Raymond R.R. Rowland photoRaymond R.R. Rowland (Kansas State University)

Structure and Nucleolar Function of SARS N Protein (2004-2006)


Emily Scott photoEmily Scott (University of Kansas)

Structure and Function of CYP17A1, a Critical Enzyme in Human Androgen Biosynthesis (2010-2012)


Irina Smirnova  photoIrina Smirnova (University of Kansas Medical Center)

Proteomic Approach to Study Diabetic Heart Protein Posttranslational Modification (2005-2007)


Liskin Swint-Kruse photoLiskin Swint-Kruse (University of Kansas Medical Center)

The Cra-FruK complex alters regulation of central metabolism of gamma-proteobacteria (2014-2015)


Liang Tang photoLiang Tang (University of Kansas)

Mechanisms of Genome Packaging in DNA Viruses (2010-2012)
Signal Transduction of Two-Component System (2008-2010)

Qize Wei photoQize Wei (Kansas State University)

Roles of MyoGEF and its Interacting Partners in Cell Division and Cell Signaling (2005-2007)


Kandatege Wimalasena photoKandatege Wimalasena (Wichita State University)

Structure-Activity Relationship Studies of Dopamine beta-Monooxygenase (2009-2012)


Liang Xu photoLiang Xu (University of Kansas)

Fragment-based drug discovery for inhibitors of RNA-binding protein HuR (2014-2015)


Asma Zaidi photoAsma Zaidi (University of Kansas) 2

Trafficking of the Plasma Membrane CA2+-ATPase to Rafts (2004-2007)


Hao Zhu, Associate Professor, Department of Clinical Laboratory Sciences, University of Kansas Medical CenterHao Zhu (University of Kansas Medical Center)

Atomic Structure of a Multi-Domain Redox Enzyme Ncb5or Implicated in Diseases (2015-2016)