Since the Center of Biomedical Research Excellence (COBRE) in Protein Structure and Function is now in Phase III of this part of Institutional Development Award (IDeA) Program; it no longer funds research investigators. The Center provides limited research funding to sustain the research environment developed in the first two phases by providing support for pilot research projects and mentoring and training activities.
Phases I and II focused in part on formal research mentoring and research project funding to junior investigators to facilitate their acquisition of preliminary data and successful competition for independent research grant support. Faculty that were selected to become COBRE investigators were early in their careers and were establishing research programs with significant emphasis on protein structure and function. COBRE investigators received research support and mentoring by a senior faculty advisor. In addition to a developing a specific research plan, COBRE investigators set specific goals for developing and submitting proposals for independent external research support.
Past Research Investigators
University of Kansas
Modulating protein function by rational design
University of Kansas
Structural characterization of cysteine-dependent acyltransferases
Kansas State University
Mechanism of chaperone-assisted assembly of proteasome regulatory particle
Structural characterization of the Anthrax toxin protective antigen
Remodeler translocation along DNA
The role of dynamics in PEPCK mediated catalysis
Mechanism and role of a novel Chlamydial transcriptional regulator CHXR
Roberto De Guzman, Ph.D.
Interactions of Salmonella needle and tip proteins
NMR studies of protein-protein interactions in the bacterial type III secretion
Audrey Lamb, Ph.D.
The Structural Biology of Pyoverdin Biosynthesis
Jennifer Laurence, Ph.D.
Redox Effects on the Structure and Dynamics of PRL-1
Julian Limburg, Ph.D.
Structure and Function of Bacterial Prolyl-4-Hydroxylase
Emily Scott, Ph.D.
Structure-Function of Mammalian Cytochromes P450
Liskin Swint-Kruse, Ph.D.
Allosteric Determinants in the Laci/Galr Family
Brian Blagg, Ph.D.
Identification of Hsp90 Cochaperones, Immunophilins, and Client Proteins
Heather Desaire, Ph.D.
Structural Characterization of Glycoproteins using Mass Spectrometry
Susan Egan, Ph.D.
Protein-Protein Interactions Required for Transcription Activation by RhaR
Jeff Staudinger, Ph.D.
Crystallization of Pregnane X Receptor Splice Variants
William Picking, Ph.D.
Subversion of Eukaryotic Cell Function by Shigella
Anna Zolkiewska, Ph.D
Structure and Function of Cell Adhesion Domain of ADAM12