Research Investigators

Since the Center of Biomedical Research Excellence (COBRE) in Protein Structure and Function is now in Phase III of this part of Institutional Development Award (IDeA) Program; it no longer funds research investigators. The Center provides limited research funding to sustain the research environment developed in the first two phases by providing support for pilot research projects and mentoring and training activities.

Phases I and II focused in part on formal research mentoring and research project funding to junior investigators to facilitate their acquisition of preliminary data and successful competition for independent research grant support. Faculty that were selected to become COBRE investigators were early in their careers and were establishing research programs with significant emphasis on protein structure and function. COBRE investigators received research support and mentoring by a senior faculty advisor. In addition to a developing a specific research plan, COBRE investigators set specific goals for developing and submitting proposals for independent external research support.

Past Research Investigators


Moriah Beck
Wichita State University
Palladin and regulation of actin dynamic

John Karanicolas
University of Kansas
Modulating protein function by rational design

Alexander Moise
University of Kansas
Structural characterization of cysteine-dependent acyltransferases

Jeroen Roelofs
Kansas State University
Mechanism of chaperone-assisted assembly of proteasome regulatory particle


James Bann
Structural characterization of the Anthrax toxin protective antigen

Christopher Fischer
Remodeler translocation along DNA

Todd Holyoak
The role of dynamics in PEPCK mediated catalysis


Scott Hefty
Mechanism and role of a novel Chlamydial transcriptional regulator CHXR


Roberto De Guzman, Ph.D.
Interactions of Salmonella needle and tip proteins
NMR studies of protein-protein interactions in the bacterial type III secretion

Audrey Lamb, Ph.D.
The Structural Biology of Pyoverdin Biosynthesis

Jennifer Laurence, Ph.D.
Redox Effects on the Structure and Dynamics of PRL-1

Julian Limburg, Ph.D.
Structure and Function of Bacterial Prolyl-4-Hydroxylase

Emily Scott, Ph.D.
Structure-Function of Mammalian Cytochromes P450

Liskin Swint-Kruse, Ph.D.
Allosteric Determinants in the Laci/Galr Family


Brian Blagg, Ph.D.
Identification of Hsp90 Cochaperones, Immunophilins, and Client Proteins

Heather Desaire, Ph.D.
Structural Characterization of Glycoproteins using Mass Spectrometry

Susan Egan, Ph.D.
Protein-Protein Interactions Required for Transcription Activation by RhaR

Jeff Staudinger, Ph.D.
Crystallization of Pregnane X Receptor Splice Variants


William Picking, Ph.D.
Subversion of Eukaryotic Cell Function by Shigella

Anna Zolkiewska, Ph.D
Structure and Function of Cell Adhesion Domain of ADAM12